Cardiovascular Remodeling and Dysfunction Across a Range of Growth Restriction Severity in Small for Gestational Age Infants – Implications for Fetal Programming
Background:The purpose of this study was to clarify cardiovascular structure and function in small for gestational age (SGA) infants across a range of intrauterine growth restriction (IUGR) severity.Methods and Results:This prospective study included 38 SGA infants and 30 appropriate for gestational...
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| Veröffentlicht in: | Circulation Journal 2016/09/23, Vol.80(10), pp.2212-2220 |
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| creator | Akazawa, Yohei Hachiya, Akira Yamazaki, Shoko Kawasaki, Yoichiro Nakamura, Chizuko Takeuchi, Yusuke Kusakari, Mai Miyosawa, Yukihide Kamiya, Motoko Motoki, Noriko Koike, Kenichi Nakamura, Tomohiko |
| description | Background:The purpose of this study was to clarify cardiovascular structure and function in small for gestational age (SGA) infants across a range of intrauterine growth restriction (IUGR) severity.Methods and Results:This prospective study included 38 SGA infants and 30 appropriate for gestational age (AGA) infants. SGA infants were subclassified into severe and mild SGA according to the degree of IUGR. Cardiovascular structure and function were evaluated using echocardiography at 1 week of age. Compared with the AGA infants, both the severe and mild SGA infants showed increased left ventricular diastolic dimensions (severe SGA 10.2±2.4, mild SGA 8.2±1.3, and AGA 7.3±0.7 mm/kg, P |
| doi_str_mv | 10.1253/circj.CJ-16-0352 |
| format | Article |
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SGA infants were subclassified into severe and mild SGA according to the degree of IUGR. Cardiovascular structure and function were evaluated using echocardiography at 1 week of age. Compared with the AGA infants, both the severe and mild SGA infants showed increased left ventricular diastolic dimensions (severe SGA 10.2±2.4, mild SGA 8.2±1.3, and AGA 7.3±0.7 mm/kg, P<0.05 for all) and decreased global longitudinal strain (severe −21.1±1.6, mild −22.5±1.8, and AGA −23.8±1.8%, P<0.05 for all). Severe SGA infants showed a decreased mitral annular early diastolic velocity (severe 5.6±1.4 vs. AGA 7.0±1.3 cm/s, P<0.01) and increased isovolumic relaxation time (severe 51.3±9.2 vs. AGA 42.7±8.2 ms, P<0.01). Weight-adjusted aortic intima-media thickness and arterial wall stiffness were significantly greater in both SGA infant groups. These cardiovascular parameters tended to deteriorate with increasing IUGR severity.Conclusions:SGA infants, including those with mild SGA, showed cardiovascular remodeling and dysfunction, which increased with IUGR severity. (Circ J 2016; 80: 2212–2220)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-16-0352</identifier><identifier>PMID: 27535477</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Cardiovascular disease ; Echocardiography ; Female ; Fetal Growth Retardation - diagnostic imaging ; Fetal Growth Retardation - physiopathology ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age ; Intrauterine growth restriction ; Male ; Prospective Studies ; Remodeling ; Small for gestational age ; Vascular Remodeling ; Ventricular Remodeling</subject><ispartof>Circulation Journal, 2016/09/23, Vol.80(10), pp.2212-2220</ispartof><rights>2016 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c623t-9bce6389bb4328a92b01a6c30911d4a0e332cce100b301102479a3c8648499a43</citedby><cites>FETCH-LOGICAL-c623t-9bce6389bb4328a92b01a6c30911d4a0e332cce100b301102479a3c8648499a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,1885,4026,27930,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27535477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akazawa, Yohei</creatorcontrib><creatorcontrib>Hachiya, Akira</creatorcontrib><creatorcontrib>Yamazaki, Shoko</creatorcontrib><creatorcontrib>Kawasaki, Yoichiro</creatorcontrib><creatorcontrib>Nakamura, Chizuko</creatorcontrib><creatorcontrib>Takeuchi, Yusuke</creatorcontrib><creatorcontrib>Kusakari, Mai</creatorcontrib><creatorcontrib>Miyosawa, Yukihide</creatorcontrib><creatorcontrib>Kamiya, Motoko</creatorcontrib><creatorcontrib>Motoki, Noriko</creatorcontrib><creatorcontrib>Koike, Kenichi</creatorcontrib><creatorcontrib>Nakamura, Tomohiko</creatorcontrib><title>Cardiovascular Remodeling and Dysfunction Across a Range of Growth Restriction Severity in Small for Gestational Age Infants – Implications for Fetal Programming</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background:The purpose of this study was to clarify cardiovascular structure and function in small for gestational age (SGA) infants across a range of intrauterine growth restriction (IUGR) severity.Methods and Results:This prospective study included 38 SGA infants and 30 appropriate for gestational age (AGA) infants. SGA infants were subclassified into severe and mild SGA according to the degree of IUGR. Cardiovascular structure and function were evaluated using echocardiography at 1 week of age. Compared with the AGA infants, both the severe and mild SGA infants showed increased left ventricular diastolic dimensions (severe SGA 10.2±2.4, mild SGA 8.2±1.3, and AGA 7.3±0.7 mm/kg, P<0.05 for all) and decreased global longitudinal strain (severe −21.1±1.6, mild −22.5±1.8, and AGA −23.8±1.8%, P<0.05 for all). Severe SGA infants showed a decreased mitral annular early diastolic velocity (severe 5.6±1.4 vs. AGA 7.0±1.3 cm/s, P<0.01) and increased isovolumic relaxation time (severe 51.3±9.2 vs. AGA 42.7±8.2 ms, P<0.01). Weight-adjusted aortic intima-media thickness and arterial wall stiffness were significantly greater in both SGA infant groups. These cardiovascular parameters tended to deteriorate with increasing IUGR severity.Conclusions:SGA infants, including those with mild SGA, showed cardiovascular remodeling and dysfunction, which increased with IUGR severity. (Circ J 2016; 80: 2212–2220)</description><subject>Cardiovascular disease</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Fetal Growth Retardation - diagnostic imaging</subject><subject>Fetal Growth Retardation - physiopathology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age</subject><subject>Intrauterine growth restriction</subject><subject>Male</subject><subject>Prospective Studies</subject><subject>Remodeling</subject><subject>Small for gestational age</subject><subject>Vascular Remodeling</subject><subject>Ventricular Remodeling</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1DAUhS0EoqWwZ4W8ZJPiv_x4OQrtMFUlUIG1deM4U4-ceLCTotnNO_AMvBi8CJ7M0G7sK93vnHt1D0JvKbmkLOcftA16c1nfZLTICM_ZM3ROuSgzUTHyfK6LTFaCn6FXMW4IYZLk8iU6Y2XOc1GW5-h3DaG1_gGinhwEfGd63xpnhzWGocUfd7GbBj1aP-CFDj5GDPgOhrXBvsPL4H-O90kTx2CP0FfzYIIdd9imugfncOcDXiYCDn1weJG0q6GDYYx_9_s_-1941W-d1XM_zvi1GRP4Jfh1gL5Pu7xGLzpw0bw5_Rfo-_XVt_pTdvt5uaoXt5kuGB8z2WhT8Eo2jeCsAskaQqHQnEhKWwHEcM60NpSQhhNKCROlBK6rQlRCShD8Ar0_-m6D_zGlpVVvozbOwWD8FBWtGJekkkwmlBzR-SrBdGobbA9hpyhRh3DUHI6qbxQt1CGcJHl3cp-a3rSPgv9pJGB5BDbpXGvzCEAYrXbm5FiRw4j0Plk_EfcQlBn4Pz_9qUA</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Akazawa, Yohei</creator><creator>Hachiya, Akira</creator><creator>Yamazaki, Shoko</creator><creator>Kawasaki, Yoichiro</creator><creator>Nakamura, Chizuko</creator><creator>Takeuchi, Yusuke</creator><creator>Kusakari, Mai</creator><creator>Miyosawa, Yukihide</creator><creator>Kamiya, Motoko</creator><creator>Motoki, Noriko</creator><creator>Koike, Kenichi</creator><creator>Nakamura, Tomohiko</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2016</creationdate><title>Cardiovascular Remodeling and Dysfunction Across a Range of Growth Restriction Severity in Small for Gestational Age Infants – Implications for Fetal Programming</title><author>Akazawa, Yohei ; Hachiya, Akira ; Yamazaki, Shoko ; Kawasaki, Yoichiro ; Nakamura, Chizuko ; Takeuchi, Yusuke ; Kusakari, Mai ; Miyosawa, Yukihide ; Kamiya, Motoko ; Motoki, Noriko ; Koike, Kenichi ; Nakamura, Tomohiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c623t-9bce6389bb4328a92b01a6c30911d4a0e332cce100b301102479a3c8648499a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cardiovascular disease</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Fetal Growth Retardation - diagnostic imaging</topic><topic>Fetal Growth Retardation - physiopathology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Small for Gestational Age</topic><topic>Intrauterine growth restriction</topic><topic>Male</topic><topic>Prospective Studies</topic><topic>Remodeling</topic><topic>Small for gestational age</topic><topic>Vascular Remodeling</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akazawa, Yohei</creatorcontrib><creatorcontrib>Hachiya, Akira</creatorcontrib><creatorcontrib>Yamazaki, Shoko</creatorcontrib><creatorcontrib>Kawasaki, Yoichiro</creatorcontrib><creatorcontrib>Nakamura, Chizuko</creatorcontrib><creatorcontrib>Takeuchi, Yusuke</creatorcontrib><creatorcontrib>Kusakari, Mai</creatorcontrib><creatorcontrib>Miyosawa, Yukihide</creatorcontrib><creatorcontrib>Kamiya, Motoko</creatorcontrib><creatorcontrib>Motoki, Noriko</creatorcontrib><creatorcontrib>Koike, Kenichi</creatorcontrib><creatorcontrib>Nakamura, Tomohiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akazawa, Yohei</au><au>Hachiya, Akira</au><au>Yamazaki, Shoko</au><au>Kawasaki, Yoichiro</au><au>Nakamura, Chizuko</au><au>Takeuchi, Yusuke</au><au>Kusakari, Mai</au><au>Miyosawa, Yukihide</au><au>Kamiya, Motoko</au><au>Motoki, Noriko</au><au>Koike, Kenichi</au><au>Nakamura, Tomohiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular Remodeling and Dysfunction Across a Range of Growth Restriction Severity in Small for Gestational Age Infants – Implications for Fetal Programming</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2016</date><risdate>2016</risdate><volume>80</volume><issue>10</issue><spage>2212</spage><epage>2220</epage><pages>2212-2220</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background:The purpose of this study was to clarify cardiovascular structure and function in small for gestational age (SGA) infants across a range of intrauterine growth restriction (IUGR) severity.Methods and Results:This prospective study included 38 SGA infants and 30 appropriate for gestational age (AGA) infants. SGA infants were subclassified into severe and mild SGA according to the degree of IUGR. Cardiovascular structure and function were evaluated using echocardiography at 1 week of age. Compared with the AGA infants, both the severe and mild SGA infants showed increased left ventricular diastolic dimensions (severe SGA 10.2±2.4, mild SGA 8.2±1.3, and AGA 7.3±0.7 mm/kg, P<0.05 for all) and decreased global longitudinal strain (severe −21.1±1.6, mild −22.5±1.8, and AGA −23.8±1.8%, P<0.05 for all). Severe SGA infants showed a decreased mitral annular early diastolic velocity (severe 5.6±1.4 vs. AGA 7.0±1.3 cm/s, P<0.01) and increased isovolumic relaxation time (severe 51.3±9.2 vs. AGA 42.7±8.2 ms, P<0.01). Weight-adjusted aortic intima-media thickness and arterial wall stiffness were significantly greater in both SGA infant groups. These cardiovascular parameters tended to deteriorate with increasing IUGR severity.Conclusions:SGA infants, including those with mild SGA, showed cardiovascular remodeling and dysfunction, which increased with IUGR severity. (Circ J 2016; 80: 2212–2220)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>27535477</pmid><doi>10.1253/circj.CJ-16-0352</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cardiovascular disease Echocardiography Female Fetal Growth Retardation - diagnostic imaging Fetal Growth Retardation - physiopathology Humans Infant, Newborn Infant, Small for Gestational Age Intrauterine growth restriction Male Prospective Studies Remodeling Small for gestational age Vascular Remodeling Ventricular Remodeling |
| title | Cardiovascular Remodeling and Dysfunction Across a Range of Growth Restriction Severity in Small for Gestational Age Infants – Implications for Fetal Programming |
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