Low molecular weight fucoidan ameliorates streptozotocin-induced hyper-responsiveness of aortic smooth muscles in type 1 diabetes rats

Low molecular weight fucoidan (LMWF) was prepared from Laminaria japonica Areschoug, a popular seafood and medicinal plant consumed in Asia. Chinese have long been using it as a traditional medicine for curing hypertension and edema. This study was intent to investigate the possible beneficial effec...

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Veröffentlicht in:	Journal of ethnopharmacology 2016-09, Vol.191, p.341-349
Hauptverfasser:	Liang, Zhengyang, Zheng, Yuanyuan, Wang, Jing, Zhang, Quanbin, Ren, Shuang, Liu, Tiantian, Wang, Zhiqiang, Luo, Dali
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology Aorta Aorta, Thoracic - drug effects Aorta, Thoracic - physiopathology Biomarkers - blood Blood Glucose - drug effects Blood Glucose - metabolism Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - physiopathology Diabetic Angiopathies - blood Diabetic Angiopathies - physiopathology Diabetic Angiopathies - prevention & control Dose-Response Relationship, Drug Fucoidan Glutathione - metabolism Hyperlipidemias - blood Hyperlipidemias - physiopathology Hyperlipidemias - prevention & control Hypertension Hypertension - blood Hypertension - physiopathology Hypertension - prevention & control Hypolipidemic Agents - chemistry Hypolipidemic Agents - pharmacology Lipids - blood Male Molecular Weight Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiopathology Oxidative Stress - drug effects Polysaccharides - chemistry Polysaccharides - pharmacology Prostaglandins - metabolism Rats, Sprague-Dawley Signal Transduction - drug effects Streptozocin Superoxide Dismutase - metabolism Superoxides - metabolism Vascular smooth muscles Vasodilation - drug effects Weight Gain - drug effects
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