5-Aminolevulinic acid coated microneedles for photodynamic therapy of skin tumors

This study evaluated the potential of coated microneedles for improved dermal delivery of 5-aminolevulinic acid (5-ALA), which naturally gets converted by cells of the tissue in to a photosensitizer called protoporphyrin IX (PPIX). Microneedle patches containing 57 microneedles were coated with 5-AL...

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Veröffentlicht in:	Journal of controlled release 2016-10, Vol.239, p.72-81
Hauptverfasser:	Jain, Amit K., Lee, Chang Hyun, Gill, Harvinder S.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-ALA Administration, Cutaneous Aminolevulinic Acid - administration & dosage Aminolevulinic Acid - metabolism Animals Coated microneedles Dose-Response Relationship, Drug Female Mice Mice, Inbred BALB C Microinjections - methods Needles Photobleaching Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - administration & dosage Photosensitizing Agents - metabolism PPIX Skin Absorption - drug effects Skin Absorption - physiology Skin cancer Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Swine
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