Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence
Pterostilbene (PS) is a well-recognized antioxidant that primarily exists in blueberries, grapevines and heartwood of red sandalwood. Interest in this compound has been renewed in recent years, and studies have found that PS possesses an array of pharmacological properties, including chemopreventive...
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| Veröffentlicht in: | European journal of pharmacology 2016-10, Vol.789, p.229-243 |
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| creator | Kosuru, Ramoji Rai, Uddipak Prakash, Swati Singh, Abhishank Singh, Sanjay |
| description | Pterostilbene (PS) is a well-recognized antioxidant that primarily exists in blueberries, grapevines and heartwood of red sandalwood. Interest in this compound has been renewed in recent years, and studies have found that PS possesses an array of pharmacological properties, including chemopreventive, antiinflammatory, antidiabetic, antidyslipidemic, antiatherosclerotic and neuroprotective effects. However, the greater in vivo bioavailability of PS, as compared to resveratrol, is an added advantage for its efficacy. This review provides a summary regarding the sources, pharmacokinetic aspects and pharmacodynamics of PS, with a focus on the molecular mechanisms underlying its protective effects against cancer, brain injuries and heart disease. Studies regarding the safety profile of PS have also been included. Based on the presently available evidence, we conclude that PS represents an active phytonutrient and a potential drug with pleiotropic health applications. |
| doi_str_mv | 10.1016/j.ejphar.2016.07.046 |
| format | Article |
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Interest in this compound has been renewed in recent years, and studies have found that PS possesses an array of pharmacological properties, including chemopreventive, antiinflammatory, antidiabetic, antidyslipidemic, antiatherosclerotic and neuroprotective effects. However, the greater in vivo bioavailability of PS, as compared to resveratrol, is an added advantage for its efficacy. This review provides a summary regarding the sources, pharmacokinetic aspects and pharmacodynamics of PS, with a focus on the molecular mechanisms underlying its protective effects against cancer, brain injuries and heart disease. Studies regarding the safety profile of PS have also been included. Based on the presently available evidence, we conclude that PS represents an active phytonutrient and a potential drug with pleiotropic health applications.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2016.07.046</identifier><identifier>PMID: 27475678</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>AMPK ; Animals ; Cardiovascular disease ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - pathology ; Central Nervous System Diseases - drug therapy ; Central Nervous System Diseases - pathology ; HO-1 ; Humans ; Neoplasms - drug therapy ; NF-κB ; Nrf2 ; Pterostilbene ; Safety ; Stilbenes - adverse effects ; Stilbenes - pharmacokinetics ; Stilbenes - pharmacology ; Stilbenes - therapeutic use</subject><ispartof>European journal of pharmacology, 2016-10, Vol.789, p.229-243</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. 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Based on the presently available evidence, we conclude that PS represents an active phytonutrient and a potential drug with pleiotropic health applications.</description><subject>AMPK</subject><subject>Animals</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - drug therapy</subject><subject>Cardiovascular Diseases - pathology</subject><subject>Central Nervous System Diseases - drug therapy</subject><subject>Central Nervous System Diseases - pathology</subject><subject>HO-1</subject><subject>Humans</subject><subject>Neoplasms - drug therapy</subject><subject>NF-κB</subject><subject>Nrf2</subject><subject>Pterostilbene</subject><subject>Safety</subject><subject>Stilbenes - adverse effects</subject><subject>Stilbenes - pharmacokinetics</subject><subject>Stilbenes - pharmacology</subject><subject>Stilbenes - therapeutic use</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVJaTZp36AEHXOxO5LllXQJhNA2hUB7aM9CksdZGa_sSNpA375aNukxp2Hg-2f4P0I-M2gZsO2XqcVp3dnU8rq1IFsQ23dkw5TUDUjGz8gGgImGa63PyUXOEwD0mvcfyDmXQvZbqTZk-pWWfcghPtKyw2RXPJTg6boUjCXYmS4jXQumJZcwO4xIbRxoKJnu0e9sDPmIh5jD465QZzMOdIl0TejnEIOvF_A5DBg9fiTvRztn_PQyL8mfb19_3903Dz-__7i7fWi84Ko0oocB5WAtilEjOs63veq1170TGjthhRqVcz0IziR0SjjngGnXcUCmOtldkuvT3TUtTwfMxdSCHufZRlwO2TDFOw2q07qi4oT6WjAnHM2awt6mv4aBOVo2kzlZNkfLBqSplmvs6uXDwe1x-B961VqBmxOAtedzwGSyD0cHQ6hiihmW8PaHfzbNkcM</recordid><startdate>20161015</startdate><enddate>20161015</enddate><creator>Kosuru, Ramoji</creator><creator>Rai, Uddipak</creator><creator>Prakash, Swati</creator><creator>Singh, Abhishank</creator><creator>Singh, Sanjay</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161015</creationdate><title>Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence</title><author>Kosuru, Ramoji ; Rai, Uddipak ; Prakash, Swati ; Singh, Abhishank ; Singh, Sanjay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-450de7daae4f9eeb2265859c95b49e34a48f8bb5042170384bbb019b320e18373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>AMPK</topic><topic>Animals</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - drug therapy</topic><topic>Cardiovascular Diseases - pathology</topic><topic>Central Nervous System Diseases - drug therapy</topic><topic>Central Nervous System Diseases - pathology</topic><topic>HO-1</topic><topic>Humans</topic><topic>Neoplasms - drug therapy</topic><topic>NF-κB</topic><topic>Nrf2</topic><topic>Pterostilbene</topic><topic>Safety</topic><topic>Stilbenes - adverse effects</topic><topic>Stilbenes - pharmacokinetics</topic><topic>Stilbenes - pharmacology</topic><topic>Stilbenes - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kosuru, Ramoji</creatorcontrib><creatorcontrib>Rai, Uddipak</creatorcontrib><creatorcontrib>Prakash, Swati</creatorcontrib><creatorcontrib>Singh, Abhishank</creatorcontrib><creatorcontrib>Singh, Sanjay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kosuru, Ramoji</au><au>Rai, Uddipak</au><au>Prakash, Swati</au><au>Singh, Abhishank</au><au>Singh, Sanjay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2016-10-15</date><risdate>2016</risdate><volume>789</volume><spage>229</spage><epage>243</epage><pages>229-243</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Pterostilbene (PS) is a well-recognized antioxidant that primarily exists in blueberries, grapevines and heartwood of red sandalwood. 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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | AMPK Animals Cardiovascular disease Cardiovascular Diseases - drug therapy Cardiovascular Diseases - pathology Central Nervous System Diseases - drug therapy Central Nervous System Diseases - pathology HO-1 Humans Neoplasms - drug therapy NF-κB Nrf2 Pterostilbene Safety Stilbenes - adverse effects Stilbenes - pharmacokinetics Stilbenes - pharmacology Stilbenes - therapeutic use |
| title | Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence |
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