Enamel Lead Biomarker for Prenatal Exposure Assessment
The development of the enamel biomarker for heavy metal exposure assessment is designed to improve studies of dose–effect relationships to embryonic anomalies, particularly neurotoxic dysfunction. This report documents initial demonstrations of ambient lead (Pb) relative to calcium (Ca) in histologi...
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| Veröffentlicht in: | Environmental research 2001-12, Vol.87 (3), p.136-140 |
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| container_title | Environmental research |
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| creator | Ericson, Jonathon E. |
| description | The development of the enamel biomarker for heavy metal exposure assessment is designed to improve studies of dose–effect relationships to embryonic anomalies, particularly neurotoxic dysfunction. This report documents initial demonstrations of ambient lead (Pb) relative to calcium (Ca) in histological cross sections of deciduous tooth enamel of three human subjects, by use of ion mass spectrometry. The goal of this research was to measure Pb and Ca in tooth enamel for use as a temporal biomarker in assessing prenatal and postnatal exposure. This involves measurement of these heavy metals in enamel at high spatial resolution along histological transects following the temporal pattern of enamel growth. The technique may be applied when completely developed to cross-sectional and longitudinal research. |
| doi_str_mv | 10.1006/enrs.2001.4283 |
| format | Article |
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This report documents initial demonstrations of ambient lead (Pb) relative to calcium (Ca) in histological cross sections of deciduous tooth enamel of three human subjects, by use of ion mass spectrometry. The goal of this research was to measure Pb and Ca in tooth enamel for use as a temporal biomarker in assessing prenatal and postnatal exposure. This involves measurement of these heavy metals in enamel at high spatial resolution along histological transects following the temporal pattern of enamel growth. The technique may be applied when completely developed to cross-sectional and longitudinal research.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1006/enrs.2001.4283</identifier><identifier>PMID: 11771927</identifier><identifier>CODEN: ENVRAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>amelogenesis ; Biological and medical sciences ; Biomarkers - analysis ; calcium ; Calcium - analysis ; Calcium Isotopes - analysis ; Central Nervous System - growth & development ; central nervous system development ; Chemical and industrial products toxicology. Toxic occupational diseases ; Child ; dental enamel ; Dental Enamel - chemistry ; Dental Enamel - metabolism ; Dose-Response Relationship, Drug ; Environmental Exposure ; Environmental Monitoring ; Female ; Humans ; lead ; Lead - analysis ; Male ; Mass Spectrometry - methods ; Medical sciences ; Metals and various inorganic compounds ; Pregnancy ; prenatal experience ; Prenatal Exposure Delayed Effects ; teeth ; tooth enamel ; Toxicology</subject><ispartof>Environmental research, 2001-12, Vol.87 (3), p.136-140</ispartof><rights>2001 Elsevier Science (USA)</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-987206e4356ca91350a4895f36dbcdf259bacd5cc281571da41dec71c5336db33</citedby><cites>FETCH-LOGICAL-c432t-987206e4356ca91350a4895f36dbcdf259bacd5cc281571da41dec71c5336db33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/enrs.2001.4283$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13442736$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11771927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ericson, Jonathon E.</creatorcontrib><title>Enamel Lead Biomarker for Prenatal Exposure Assessment</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>The development of the enamel biomarker for heavy metal exposure assessment is designed to improve studies of dose–effect relationships to embryonic anomalies, particularly neurotoxic dysfunction. This report documents initial demonstrations of ambient lead (Pb) relative to calcium (Ca) in histological cross sections of deciduous tooth enamel of three human subjects, by use of ion mass spectrometry. The goal of this research was to measure Pb and Ca in tooth enamel for use as a temporal biomarker in assessing prenatal and postnatal exposure. This involves measurement of these heavy metals in enamel at high spatial resolution along histological transects following the temporal pattern of enamel growth. The technique may be applied when completely developed to cross-sectional and longitudinal research.</description><subject>amelogenesis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>calcium</subject><subject>Calcium - analysis</subject><subject>Calcium Isotopes - analysis</subject><subject>Central Nervous System - growth & development</subject><subject>central nervous system development</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Child</subject><subject>dental enamel</subject><subject>Dental Enamel - chemistry</subject><subject>Dental Enamel - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Environmental Exposure</subject><subject>Environmental Monitoring</subject><subject>Female</subject><subject>Humans</subject><subject>lead</subject><subject>Lead - analysis</subject><subject>Male</subject><subject>Mass Spectrometry - methods</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Pregnancy</subject><subject>prenatal experience</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>teeth</subject><subject>tooth enamel</subject><subject>Toxicology</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1LwzAYwPEgipvTq0fpRW-deW2b4xzzBQZ60HPIkqdQ7cvM04p-e1M22Ek8hYRfHpI_IZeMzhml2S20AeecUjaXvBBHZMqozlKqlTgm03gsUi0Um5AzxPe4ZUrQUzJhLM-Z5vmUZKvWNlAna7A-uau6xoYPCEnZheQlQGt7Wyer722HQ4BkgQiIDbT9OTkpbY1wsV9n5O1-9bp8TNfPD0_LxTp1UvA-1UXOaQZSqMxZzYSiVhZalSLzG-dLrvTGOq-c4wVTOfNWMg8uZ06JkQgxIze7udvQfQ6AvWkqdFDXtoVuQMMKLlQu8_-hVLrgsohwvoMudIgBSrMNVfz1j2HUjEnNmNSMSc2YNF642k8eNg34A983jOB6Dyw6W5fBtq7CgxNSRpVFV-wcxGBfFQSDroLWga8CuN74rvrrDb-Ha5DE</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Ericson, Jonathon E.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7QP</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope></search><sort><creationdate>20011201</creationdate><title>Enamel Lead Biomarker for Prenatal Exposure Assessment</title><author>Ericson, Jonathon E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-987206e4356ca91350a4895f36dbcdf259bacd5cc281571da41dec71c5336db33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>amelogenesis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>calcium</topic><topic>Calcium - analysis</topic><topic>Calcium Isotopes - analysis</topic><topic>Central Nervous System - growth & development</topic><topic>central nervous system development</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Child</topic><topic>dental enamel</topic><topic>Dental Enamel - chemistry</topic><topic>Dental Enamel - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Environmental Exposure</topic><topic>Environmental Monitoring</topic><topic>Female</topic><topic>Humans</topic><topic>lead</topic><topic>Lead - analysis</topic><topic>Male</topic><topic>Mass Spectrometry - methods</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Pregnancy</topic><topic>prenatal experience</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>teeth</topic><topic>tooth enamel</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ericson, Jonathon E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ericson, Jonathon E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enamel Lead Biomarker for Prenatal Exposure Assessment</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>87</volume><issue>3</issue><spage>136</spage><epage>140</epage><pages>136-140</pages><issn>0013-9351</issn><eissn>1096-0953</eissn><coden>ENVRAL</coden><abstract>The development of the enamel biomarker for heavy metal exposure assessment is designed to improve studies of dose–effect relationships to embryonic anomalies, particularly neurotoxic dysfunction. This report documents initial demonstrations of ambient lead (Pb) relative to calcium (Ca) in histological cross sections of deciduous tooth enamel of three human subjects, by use of ion mass spectrometry. The goal of this research was to measure Pb and Ca in tooth enamel for use as a temporal biomarker in assessing prenatal and postnatal exposure. This involves measurement of these heavy metals in enamel at high spatial resolution along histological transects following the temporal pattern of enamel growth. The technique may be applied when completely developed to cross-sectional and longitudinal research.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>11771927</pmid><doi>10.1006/enrs.2001.4283</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0013-9351 |
| ispartof | Environmental research, 2001-12, Vol.87 (3), p.136-140 |
| issn | 0013-9351 1096-0953 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | amelogenesis Biological and medical sciences Biomarkers - analysis calcium Calcium - analysis Calcium Isotopes - analysis Central Nervous System - growth & development central nervous system development Chemical and industrial products toxicology. Toxic occupational diseases Child dental enamel Dental Enamel - chemistry Dental Enamel - metabolism Dose-Response Relationship, Drug Environmental Exposure Environmental Monitoring Female Humans lead Lead - analysis Male Mass Spectrometry - methods Medical sciences Metals and various inorganic compounds Pregnancy prenatal experience Prenatal Exposure Delayed Effects teeth tooth enamel Toxicology |
| title | Enamel Lead Biomarker for Prenatal Exposure Assessment |
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