PKC ζ Enhances Insulin-like Growth Factor 1-Dependent Mitogenic Activity in the Rat Clonal β Cell Line RIN 1046-38

Protein kinase C seems to be linked to the regulation of insulin secretion as well as mitogenic signaling in pancreatic β cells. To study the impact of different PKC isoforms on insulin secretion and mitogenic activity we stably overexpressed the PKC isoforms α, β2, ε, and ζ in the rat clonal β cell...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002-01, Vol.290 (1), p.85-90
Hauptverfasser:	Hennige, Anita M., Fritsche, Andreas, Strack, Volker, Weigert, Cora, Mischak, Harald, Borboni, Patricia, Renn, Walter, Häring, Hans-Ulrich, Kellerer, Monika
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Nucleus - metabolism DNA, Complementary - metabolism Enzyme Inhibitors - pharmacology Glucose - metabolism Glucose - pharmacology Homeodomain Proteins Insulin - biosynthesis Insulin - genetics Insulin - metabolism insulin secretion Insulin-Like Growth Factor I - metabolism Islets of Langerhans - enzymology Microscopy, Fluorescence mitogenesis mitogenic activity PDX-1 PDX-1 protein PKC ζ Promoter Regions, Genetic Protein Binding Protein Isoforms Protein Kinase C - metabolism Protein Kinase C - physiology Rats RIN 1046-38 cells Tetradecanoylphorbol Acetate - pharmacology Thymidine - metabolism Trans-Activators - biosynthesis Transfection
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