Effects of hydrogen sulfide on cognitive dysfunction and NR2B in rats

Abstract Background Hepatic ischemia/reperfusion (hepatic I/R) has been found to induce cognitive dysfunction. The NR2B subunit of N-methyl-D-aspartate (NMDA) receptors is a major factor in memory and learning processes, and hydrogen sulfide (H2 S) may modulate this NMDA receptor. Therefore, in this...

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Veröffentlicht in:	The Journal of surgical research 2016-10, Vol.205 (2), p.426-431
Hauptverfasser:	Tu, Fa-Ping, MD, Li, Jun-Xiang, MD, Li, Qiang, MD, Wang, Ji, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Blotting, Western Cognitive dysfunction Cognitive Dysfunction - etiology Cognitive Dysfunction - metabolism Cognitive Dysfunction - prevention & control Drug Administration Schedule Hepatic ischemia/reperfusion Hippocampus - drug effects Hippocampus - metabolism Hydrogen sulfide Hydrogen Sulfide - pharmacology Injections, Intraperitoneal Liver Diseases - complications Male Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NR2B Random Allocation Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism Reperfusion Injury - complications Reverse Transcriptase Polymerase Chain Reaction Sulfides - pharmacology Sulfides - therapeutic use Surgery Treatment Outcome
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