Early Activation of Th2/Th22 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions

Determining inflammation and itch pathway activation in patients with atopic dermatitis (AD) is fraught with the inability to precisely assess the age of skin lesions, thus affecting the analysis of time-dependent mediators. To characterize inflammatory events occurring during early experimental acu...

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Veröffentlicht in:	Journal of investigative dermatology 2016-10, Vol.136 (10), p.1961-1969
Hauptverfasser:	Olivry, Thierry, Mayhew, David, Paps, Judy S., Linder, Keith E., Peredo, Carlos, Rajpal, Deepak, Hofland, Hans, Cote-Sierra, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - immunology Animals Cytokines - genetics Cytokines - immunology Dermatitis, Atopic - immunology Dermatophagoides farinae - immunology Disease Models, Animal Dogs Female Immunity, Innate - immunology Inflammation - immunology Interleukin-22 Interleukin-9 - genetics Interleukin-9 - immunology Interleukins - genetics Interleukins - immunology Male Pruritus - immunology Skin - immunology Skin - pathology Species Specificity Th2 Cells - immunology Time Factors Up-Regulation - genetics
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