The IL-7 Receptor Controls the Accessibility of the TCRγ Locus by Stat5 and Histone Acetylation

The IL-7 receptor (IL-7R) plays critical roles in expansion and V(D)J recombination during lymphocyte development. Here we demonstrate that cytokine stimulation rapidly recruits Stat5 and transcriptional coactivators to the Jγ germline promoter and induces histone acetylation, germline transcription...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2001-11, Vol.15 (5), p.813-823
Hauptverfasser:	Ye, Sang-Kyu, Agata, Yasutoshi, Lee, Hai-Chon, Kurooka, Hisanori, Kitamura, Toshio, Shimizu, Akira, Honjo, Tasuku, Ikuta, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	histone deacetylase inhibitors histones interleukin 7 receptors Stat5 protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!