Comparison of tissue sources for the skin integrity function test (SIFT)

One of the in vitro models involved in an ECVAM-sponsored prevalidation study for acute skin irritation is the skin integrity function test (SIFT), which utilises full-thickness mouse skin. We have evaluated nine different skin types in order to identify the most useful model for assessing skin barr...

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Veröffentlicht in:	Toxicology in vitro 2001-08, Vol.15 (4), p.597-600
Hauptverfasser:	Heylings, J.R, Clowes, H.M, Hughes, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative methods Animal Testing Alternatives - methods Animal Testing Alternatives - standards Animals Biological and medical sciences Body Water - metabolism Electric Impedance Female General aspects. Methods Humans In vitro Irritants - adverse effects Male Medical sciences Mice Mice, Inbred BALB C Mouse Permeability - drug effects Rabbits Rats Rats, Wistar Skin - drug effects Skin - metabolism Skin integrity function test (SIFT) Skin Irritancy Tests - methods Skin Irritancy Tests - standards Skin irritation Skin Physiological Phenomena - drug effects Sodium Dodecyl Sulfate - adverse effects Species Specificity Swine Toxicology Validation Water Loss, Insensible - drug effects
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