Sweet syndrome: long-term follow-up of 138 patients
Summary Background Several studies support a strong association of Sweet syndrome (SS) with malignancy. However, only a few studies analysing the clinical features of malignancy‐associated SS have been published in recent years. Aim To retrospectively study the clinical features of SS that could pre...
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| Veröffentlicht in: | Clinical and experimental dermatology 2016-10, Vol.41 (7), p.741-746 |
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| creator | Marcoval, J. Martín-Callizo, C. Valentí-Medina, F. Bonfill-Ortí, M. Martínez-Molina, L. |
| description | Summary
Background
Several studies support a strong association of Sweet syndrome (SS) with malignancy. However, only a few studies analysing the clinical features of malignancy‐associated SS have been published in recent years.
Aim
To retrospectively study the clinical features of SS that could predict the development of associated malignancies and to analyse the development of malignant neoplasia during long‐term follow‐up of patients with SS.
Methods
Clinical features of the patients diagnosed with SS syndrome between 1987 and 2013 at Bellvitge Hospital (Barcelona, Spain) were retrospectively analysed.
Results
In total, 138 patients were included in the study (66 male, 72 female, mean ± SD age 51.24 ± 14.11 years). SS was associated with haematological malignancy in 31 cases, infection in 23, inflammatory bowel disease in 12, inflammatory systemic disease in 8, and solid tumours in 4. It was drug‐induced in 5 cases and idiopathic in 54. In four patients, an underlying haematological disease that was considered related to SS was diagnosed between 4 and 16 months after SS presentation. Variables significantly associated with malignancy in multivariate logistic regression analysis were age (OR = 1.08 for each increasing year, P = 0.01), anaemia (OR = 9.38, P = 0.001), thrombocytopenia (OR = 16.10, P |
| doi_str_mv | 10.1111/ced.12899 |
| format | Article |
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Background
Several studies support a strong association of Sweet syndrome (SS) with malignancy. However, only a few studies analysing the clinical features of malignancy‐associated SS have been published in recent years.
Aim
To retrospectively study the clinical features of SS that could predict the development of associated malignancies and to analyse the development of malignant neoplasia during long‐term follow‐up of patients with SS.
Methods
Clinical features of the patients diagnosed with SS syndrome between 1987 and 2013 at Bellvitge Hospital (Barcelona, Spain) were retrospectively analysed.
Results
In total, 138 patients were included in the study (66 male, 72 female, mean ± SD age 51.24 ± 14.11 years). SS was associated with haematological malignancy in 31 cases, infection in 23, inflammatory bowel disease in 12, inflammatory systemic disease in 8, and solid tumours in 4. It was drug‐induced in 5 cases and idiopathic in 54. In four patients, an underlying haematological disease that was considered related to SS was diagnosed between 4 and 16 months after SS presentation. Variables significantly associated with malignancy in multivariate logistic regression analysis were age (OR = 1.08 for each increasing year, P = 0.01), anaemia (OR = 9.38, P = 0.001), thrombocytopenia (OR = 16.10, P < 0.01) and absence of arthralgia (OR = 11.13, P < 0.01).
Conclusions
Patients with older age, anaemia or thrombocytopenia, and without arthralgia are more likely to have malignancy‐associated SS. We recommend that patients with SS without clear aetiology should be followed up for at least 16 months to exclude a possible underlying haematological malignancy.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/ced.12899</identifier><identifier>PMID: 27663147</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Hematologic Neoplasms - etiology ; Hematologic Neoplasms - pathology ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Spain ; Sweet Syndrome - complications ; Sweet Syndrome - pathology ; Sweet Syndrome - therapy ; Time Factors ; Young Adult</subject><ispartof>Clinical and experimental dermatology, 2016-10, Vol.41 (7), p.741-746</ispartof><rights>2016 British Association of Dermatologists</rights><rights>2016 British Association of Dermatologists.</rights><rights>Copyright © 2016 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3919-4f2faedacd32020eb0d0a5dc4b0433e768ffd5d2fbe7d7d41c9f1f63a593c90f3</citedby><cites>FETCH-LOGICAL-c3919-4f2faedacd32020eb0d0a5dc4b0433e768ffd5d2fbe7d7d41c9f1f63a593c90f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27663147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marcoval, J.</creatorcontrib><creatorcontrib>Martín-Callizo, C.</creatorcontrib><creatorcontrib>Valentí-Medina, F.</creatorcontrib><creatorcontrib>Bonfill-Ortí, M.</creatorcontrib><creatorcontrib>Martínez-Molina, L.</creatorcontrib><title>Sweet syndrome: long-term follow-up of 138 patients</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Background
Several studies support a strong association of Sweet syndrome (SS) with malignancy. However, only a few studies analysing the clinical features of malignancy‐associated SS have been published in recent years.
Aim
To retrospectively study the clinical features of SS that could predict the development of associated malignancies and to analyse the development of malignant neoplasia during long‐term follow‐up of patients with SS.
Methods
Clinical features of the patients diagnosed with SS syndrome between 1987 and 2013 at Bellvitge Hospital (Barcelona, Spain) were retrospectively analysed.
Results
In total, 138 patients were included in the study (66 male, 72 female, mean ± SD age 51.24 ± 14.11 years). SS was associated with haematological malignancy in 31 cases, infection in 23, inflammatory bowel disease in 12, inflammatory systemic disease in 8, and solid tumours in 4. It was drug‐induced in 5 cases and idiopathic in 54. In four patients, an underlying haematological disease that was considered related to SS was diagnosed between 4 and 16 months after SS presentation. Variables significantly associated with malignancy in multivariate logistic regression analysis were age (OR = 1.08 for each increasing year, P = 0.01), anaemia (OR = 9.38, P = 0.001), thrombocytopenia (OR = 16.10, P < 0.01) and absence of arthralgia (OR = 11.13, P < 0.01).
Conclusions
Patients with older age, anaemia or thrombocytopenia, and without arthralgia are more likely to have malignancy‐associated SS. We recommend that patients with SS without clear aetiology should be followed up for at least 16 months to exclude a possible underlying haematological malignancy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hematologic Neoplasms - etiology</subject><subject>Hematologic Neoplasms - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Spain</subject><subject>Sweet Syndrome - complications</subject><subject>Sweet Syndrome - pathology</subject><subject>Sweet Syndrome - therapy</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtKxDAUBuAgio6XhS8gBTe6qCY5bdK6k3G8oCjibRkyzYlU22ZMWsZ5ezuO40Iwm0D4zk_OT8guo0esP8cFmiPGszxfIQMGIo05B7pKBhSojEUO2QbZDOGNUgZMputkg0shgCVyQOBhithGYdYY72o8iSrXvMYt-jqyrqrcNO4mkbMRgyya6LbEpg3bZM3qKuDOz71Fns5Hj8PL-Obu4mp4ehMXkLM8Tiy3Go0uDHDKKY6poTo1RTKmCQBKkVlrUsPtGKWRJmFFbpkVoNMcipxa2CIHi9yJdx8dhlbVZSiwqnSDrguKZf2aIKRIerr_h765zjf97-aKpwln2VwdLlThXQgerZr4stZ-phhV8yZV36T6brK3ez-J3bjuX5dyWV0PjhdgWlY4-z9JDUdny8h4MVGGFj9_J7R_V0KCTNXL7YVi188ye75-UPfwBciAikA</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Marcoval, J.</creator><creator>Martín-Callizo, C.</creator><creator>Valentí-Medina, F.</creator><creator>Bonfill-Ortí, M.</creator><creator>Martínez-Molina, L.</creator><general>Blackwell Publishing Ltd</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201610</creationdate><title>Sweet syndrome: long-term follow-up of 138 patients</title><author>Marcoval, J. ; Martín-Callizo, C. ; Valentí-Medina, F. ; Bonfill-Ortí, M. ; Martínez-Molina, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3919-4f2faedacd32020eb0d0a5dc4b0433e768ffd5d2fbe7d7d41c9f1f63a593c90f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hematologic Neoplasms - etiology</topic><topic>Hematologic Neoplasms - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Spain</topic><topic>Sweet Syndrome - complications</topic><topic>Sweet Syndrome - pathology</topic><topic>Sweet Syndrome - therapy</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marcoval, J.</creatorcontrib><creatorcontrib>Martín-Callizo, C.</creatorcontrib><creatorcontrib>Valentí-Medina, F.</creatorcontrib><creatorcontrib>Bonfill-Ortí, M.</creatorcontrib><creatorcontrib>Martínez-Molina, L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marcoval, J.</au><au>Martín-Callizo, C.</au><au>Valentí-Medina, F.</au><au>Bonfill-Ortí, M.</au><au>Martínez-Molina, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sweet syndrome: long-term follow-up of 138 patients</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2016-10</date><risdate>2016</risdate><volume>41</volume><issue>7</issue><spage>741</spage><epage>746</epage><pages>741-746</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
Background
Several studies support a strong association of Sweet syndrome (SS) with malignancy. However, only a few studies analysing the clinical features of malignancy‐associated SS have been published in recent years.
Aim
To retrospectively study the clinical features of SS that could predict the development of associated malignancies and to analyse the development of malignant neoplasia during long‐term follow‐up of patients with SS.
Methods
Clinical features of the patients diagnosed with SS syndrome between 1987 and 2013 at Bellvitge Hospital (Barcelona, Spain) were retrospectively analysed.
Results
In total, 138 patients were included in the study (66 male, 72 female, mean ± SD age 51.24 ± 14.11 years). SS was associated with haematological malignancy in 31 cases, infection in 23, inflammatory bowel disease in 12, inflammatory systemic disease in 8, and solid tumours in 4. It was drug‐induced in 5 cases and idiopathic in 54. In four patients, an underlying haematological disease that was considered related to SS was diagnosed between 4 and 16 months after SS presentation. Variables significantly associated with malignancy in multivariate logistic regression analysis were age (OR = 1.08 for each increasing year, P = 0.01), anaemia (OR = 9.38, P = 0.001), thrombocytopenia (OR = 16.10, P < 0.01) and absence of arthralgia (OR = 11.13, P < 0.01).
Conclusions
Patients with older age, anaemia or thrombocytopenia, and without arthralgia are more likely to have malignancy‐associated SS. We recommend that patients with SS without clear aetiology should be followed up for at least 16 months to exclude a possible underlying haematological malignancy.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27663147</pmid><doi>10.1111/ced.12899</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical and experimental dermatology, 2016-10, Vol.41 (7), p.741-746 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Female Follow-Up Studies Hematologic Neoplasms - etiology Hematologic Neoplasms - pathology Humans Male Middle Aged Retrospective Studies Risk Factors Spain Sweet Syndrome - complications Sweet Syndrome - pathology Sweet Syndrome - therapy Time Factors Young Adult |
| title | Sweet syndrome: long-term follow-up of 138 patients |
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