Use of Permeapad® for prediction of buccal absorption: A comparison to in vitro, ex vivo and in vivo method

The present work explores the usefulness of Permeapad® for prediction of buccal absorption. Permeability studies with the model drug metoprolol were carried out using the Permeapad® barrier at pH values 7.4; 8.5; 9.0, and 9.5. It was confirmed that Permeapad® can withstand these conditions, and as e...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2016-10, Vol.93, p.399-404
Hauptverfasser:	Bibi, Hanady Ajine, Holm, René, Bauer-Brandl, Annette
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Buccal absorption Drug Delivery Systems Hydrogen-Ion Concentration In vitro In Vitro Techniques IVIVC Metoprolol Metoprolol - administration & dosage Metoprolol - pharmacokinetics Mouth Mucosa - metabolism Oral Mucosal Absorption Permeability Permeapad Swine Swine, Miniature
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