Risk factors for the severity and mortality of pneumococcal pneumonia: Importance of premorbid patients' performance status
Abstract Comorbidity is known to be associated with the severity and mortality of pneumonia. The severity of each underlying disease varies, and performance status, which is known to be a prognostic factor of malignant diseases, reflects the overall patient condition as affected by his/her comorbidi...
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| Veröffentlicht in: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2016-10, Vol.22 (10), p.685-691 |
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| container_title | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy |
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| creator | Ishiguro, Takashi Kagiyama, Naho Uozumi, Ryuji Odashima, Kyuto Kurashima, Kazuyoshi Morita, Satoshi Takayanagi, Noboru |
| description | Abstract Comorbidity is known to be associated with the severity and mortality of pneumonia. The severity of each underlying disease varies, and performance status, which is known to be a prognostic factor of malignant diseases, reflects the overall patient condition as affected by his/her comorbidity and underlying diseases of various severity. We investigated whether premorbid patients' performance status is associated with the severity and mortality of pneumococcal pneumonia. This retrospective study assessed these factors in hospitalized patients suffering from pneumococcal pneumonia from 2002 to 2015. We included 424 patients aged 68.9 ± 14.1 years in the study, of which 68.9% were men. A multivariate analysis found that advanced age (≥65 years), diabetes mellitus, and poor performance status were independent factors associated with severity, whereas old pulmonary tuberculosis, poor performance status, pneumococcal bacteremia, and severe pneumonia were independent factors that were associated with non-survival. Poor performance status was associated with the severity and mortality of pneumococcal pneumonia. |
| doi_str_mv | 10.1016/j.jiac.2016.07.008 |
| format | Article |
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The severity of each underlying disease varies, and performance status, which is known to be a prognostic factor of malignant diseases, reflects the overall patient condition as affected by his/her comorbidity and underlying diseases of various severity. We investigated whether premorbid patients' performance status is associated with the severity and mortality of pneumococcal pneumonia. This retrospective study assessed these factors in hospitalized patients suffering from pneumococcal pneumonia from 2002 to 2015. We included 424 patients aged 68.9 ± 14.1 years in the study, of which 68.9% were men. A multivariate analysis found that advanced age (≥65 years), diabetes mellitus, and poor performance status were independent factors associated with severity, whereas old pulmonary tuberculosis, poor performance status, pneumococcal bacteremia, and severe pneumonia were independent factors that were associated with non-survival. Poor performance status was associated with the severity and mortality of pneumococcal pneumonia.</description><identifier>ISSN: 1341-321X</identifier><identifier>EISSN: 1437-7780</identifier><identifier>DOI: 10.1016/j.jiac.2016.07.008</identifier><identifier>PMID: 27593263</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Activities of Daily Living ; Age Factors ; Aged ; Aged, 80 and over ; Bacteremia - epidemiology ; Comorbidity ; Diabetes Mellitus - epidemiology ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Japan - epidemiology ; Male ; Middle Aged ; Mortality ; Performance status ; Pneumococcal pneumonia ; Pneumonia, Pneumococcal - microbiology ; Pneumonia, Pneumococcal - mortality ; Prognosis ; Prognostic factor ; Retrospective Studies ; Risk Factors ; Severe ; Severity of Illness Index ; Streptococcus pneumoniae ; Streptococcus pneumoniae - isolation & purification ; Tuberculosis, Pulmonary - epidemiology</subject><ispartof>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2016-10, Vol.22 (10), p.685-691</ispartof><rights>Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases</rights><rights>2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases</rights><rights>Copyright © 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-d44142efd7b88e518382743f2d87ea18b9141d79f3a031cd25177ef85935622e3</citedby><cites>FETCH-LOGICAL-c501t-d44142efd7b88e518382743f2d87ea18b9141d79f3a031cd25177ef85935622e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27593263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishiguro, Takashi</creatorcontrib><creatorcontrib>Kagiyama, Naho</creatorcontrib><creatorcontrib>Uozumi, Ryuji</creatorcontrib><creatorcontrib>Odashima, Kyuto</creatorcontrib><creatorcontrib>Kurashima, Kazuyoshi</creatorcontrib><creatorcontrib>Morita, Satoshi</creatorcontrib><creatorcontrib>Takayanagi, Noboru</creatorcontrib><title>Risk factors for the severity and mortality of pneumococcal pneumonia: Importance of premorbid patients' performance status</title><title>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</title><addtitle>J Infect Chemother</addtitle><description>Abstract Comorbidity is known to be associated with the severity and mortality of pneumonia. The severity of each underlying disease varies, and performance status, which is known to be a prognostic factor of malignant diseases, reflects the overall patient condition as affected by his/her comorbidity and underlying diseases of various severity. We investigated whether premorbid patients' performance status is associated with the severity and mortality of pneumococcal pneumonia. This retrospective study assessed these factors in hospitalized patients suffering from pneumococcal pneumonia from 2002 to 2015. We included 424 patients aged 68.9 ± 14.1 years in the study, of which 68.9% were men. A multivariate analysis found that advanced age (≥65 years), diabetes mellitus, and poor performance status were independent factors associated with severity, whereas old pulmonary tuberculosis, poor performance status, pneumococcal bacteremia, and severe pneumonia were independent factors that were associated with non-survival. Poor performance status was associated with the severity and mortality of pneumococcal pneumonia.</description><subject>Activities of Daily Living</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bacteremia - epidemiology</subject><subject>Comorbidity</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Performance status</subject><subject>Pneumococcal pneumonia</subject><subject>Pneumonia, Pneumococcal - microbiology</subject><subject>Pneumonia, Pneumococcal - mortality</subject><subject>Prognosis</subject><subject>Prognostic factor</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Severe</subject><subject>Severity of Illness Index</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Tuberculosis, Pulmonary - epidemiology</subject><issn>1341-321X</issn><issn>1437-7780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2L1TAUhosozjj6B1xIdrppzUnSJldEkMGPgQHBD3AXcpNTTKdtapIOXPzzpnOvLly4ygk87wvnOVX1FGgDFLqXQzN4YxtW5obKhlJ1rzoHwWUtpaL3y8wF1JzB97PqUUoDpSBbpR5WZ0y2O846fl79-uzTDemNzSEm0odI8g8kCW8x-nwgZnZkCjGbcfuFniwzrlOwwVoznj6zN6_I1bRs2GzxjopYUnvvyGKyxzmn52TBWOqnOyRlk9f0uHrQmzHhk9N7UX17_-7r5cf6-tOHq8u317VtKeTaCQGCYe_kXilsQXHFpOA9c0qiAbXfgQAndz03lIN1rAUpsVdlxbZjDPlF9eLYu8Twc8WU9eSTxXE0M4Y1aVCMiW7HhCooO6I2hpQi9nqJfjLxoIHqTboe9CZdb9I1lbpIL6Fnp_51P6H7G_ljuQCvjwCWLW89Rp1ssWLR-Yg2axf8__vf_BO3o599ucANHjANYY1z8adBJ6ap_rKdfbs6dJwC44L_BkShqY0</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Ishiguro, Takashi</creator><creator>Kagiyama, Naho</creator><creator>Uozumi, Ryuji</creator><creator>Odashima, Kyuto</creator><creator>Kurashima, Kazuyoshi</creator><creator>Morita, Satoshi</creator><creator>Takayanagi, Noboru</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Risk factors for the severity and mortality of pneumococcal pneumonia: Importance of premorbid patients' performance status</title><author>Ishiguro, Takashi ; Kagiyama, Naho ; Uozumi, Ryuji ; Odashima, Kyuto ; Kurashima, Kazuyoshi ; Morita, Satoshi ; Takayanagi, Noboru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-d44142efd7b88e518382743f2d87ea18b9141d79f3a031cd25177ef85935622e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Activities of Daily Living</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bacteremia - epidemiology</topic><topic>Comorbidity</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Performance status</topic><topic>Pneumococcal pneumonia</topic><topic>Pneumonia, Pneumococcal - microbiology</topic><topic>Pneumonia, Pneumococcal - mortality</topic><topic>Prognosis</topic><topic>Prognostic factor</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Severe</topic><topic>Severity of Illness Index</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><topic>Tuberculosis, Pulmonary - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishiguro, Takashi</creatorcontrib><creatorcontrib>Kagiyama, Naho</creatorcontrib><creatorcontrib>Uozumi, Ryuji</creatorcontrib><creatorcontrib>Odashima, Kyuto</creatorcontrib><creatorcontrib>Kurashima, Kazuyoshi</creatorcontrib><creatorcontrib>Morita, Satoshi</creatorcontrib><creatorcontrib>Takayanagi, Noboru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishiguro, Takashi</au><au>Kagiyama, Naho</au><au>Uozumi, Ryuji</au><au>Odashima, Kyuto</au><au>Kurashima, Kazuyoshi</au><au>Morita, Satoshi</au><au>Takayanagi, Noboru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for the severity and mortality of pneumococcal pneumonia: Importance of premorbid patients' performance status</atitle><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle><addtitle>J Infect Chemother</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>22</volume><issue>10</issue><spage>685</spage><epage>691</epage><pages>685-691</pages><issn>1341-321X</issn><eissn>1437-7780</eissn><abstract>Abstract Comorbidity is known to be associated with the severity and mortality of pneumonia. The severity of each underlying disease varies, and performance status, which is known to be a prognostic factor of malignant diseases, reflects the overall patient condition as affected by his/her comorbidity and underlying diseases of various severity. We investigated whether premorbid patients' performance status is associated with the severity and mortality of pneumococcal pneumonia. This retrospective study assessed these factors in hospitalized patients suffering from pneumococcal pneumonia from 2002 to 2015. We included 424 patients aged 68.9 ± 14.1 years in the study, of which 68.9% were men. A multivariate analysis found that advanced age (≥65 years), diabetes mellitus, and poor performance status were independent factors associated with severity, whereas old pulmonary tuberculosis, poor performance status, pneumococcal bacteremia, and severe pneumonia were independent factors that were associated with non-survival. Poor performance status was associated with the severity and mortality of pneumococcal pneumonia.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>27593263</pmid><doi>10.1016/j.jiac.2016.07.008</doi><tpages>7</tpages></addata></record> |
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| subjects | Activities of Daily Living Age Factors Aged Aged, 80 and over Bacteremia - epidemiology Comorbidity Diabetes Mellitus - epidemiology Female Hematology, Oncology and Palliative Medicine Humans Japan - epidemiology Male Middle Aged Mortality Performance status Pneumococcal pneumonia Pneumonia, Pneumococcal - microbiology Pneumonia, Pneumococcal - mortality Prognosis Prognostic factor Retrospective Studies Risk Factors Severe Severity of Illness Index Streptococcus pneumoniae Streptococcus pneumoniae - isolation & purification Tuberculosis, Pulmonary - epidemiology |
| title | Risk factors for the severity and mortality of pneumococcal pneumonia: Importance of premorbid patients' performance status |
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