Structural Characterization of Cross-Linked Species in Trastuzumab Emtansine (Kadcyla)

The antibody–drug conjugate, trastuzumab emtansine (Kadcyla), is produced by attachment of the antitubulin drug, DM1, to lysine amines via a heterobifunctional linker, SMCC (succinimidyl 4-(N-maleimidomethyl)­cyclohexane-1-carboxylate). Following the reaction of the N-hydroxysuccinimide activated li...

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Veröffentlicht in:	Bioconjugate chemistry 2016-09, Vol.27 (9), p.2037-2047
Hauptverfasser:	Chen, Yan, Kim, Michael T., Zheng, Laura, Deperalta, Galahad, Jacobson, Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Monoclonal, Humanized - chemistry Lysine - chemistry Maleimides - chemistry Maytansine - analogs & derivatives Maytansine - chemistry Models, Molecular Peptides - chemistry Protein Structure, Secondary Trastuzumab
Online-Zugang:	Volltext
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