Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a preferential loss of the dopaminergic neurons of the substantia nigra pars compacta. Although the etiology of PD is unknown, major biochemical processes such as oxidative stress and mitochondrial inhibition are largely...

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Veröffentlicht in:	Progress in neurobiology 2001-10, Vol.65 (2), p.135-172
Hauptverfasser:	Blum, D, Torch, S, Lambeng, N, Nissou, M, Benabid, A L, Sadoul, R, Verna, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Dopamine - toxicity Humans MPTP Poisoning - metabolism Nerve Degeneration - chemically induced Nerve Degeneration - metabolism Oxidopamine - toxicity Sympatholytics - toxicity
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