Diacylglycerol (DAG)-lactones, a New Class of Protein Kinase C (PKC) Agonists, Induce Apoptosis in LNCaP Prostate Cancer Cells by Selective Activation of PKCα

Phorbol esters, the archetypical (PKC) activators, induce apoptosis in androgen-sensitive LNCaP prostate cancer cells. In this study we evaluate the effect of a novel class of PKC ligands, the diacylglycerol (DAG)-lactones, as inducers of apoptosis in LNCaP cells. These unique ligands were designed...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2002-01, Vol.277 (1), p.645-655
Hauptverfasser:	Garcia-Bermejo, Maria Laura, Leskow, Federico Coluccio, Fujii, Teruhiko, Wang, Qiming, Blumberg, Peter M., Ohba, Motoi, Kuroki, Toshio, Han, Kee-Chung, Lee, Jeewoo, Marquez, Victor E., Kazanietz, Marcelo G.
Format:	Artikel
Sprache:	eng
Schlagworte:	dialglycerol lactones prostate carcinoma
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!