Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases

The repair of T:G mismatches in DNA is key for maintaining bacterial restriction/modification systems and gene silencing in higher eukaryotes. T:G mismatch repair can be initiated by a specific mismatch glycosylase (MIG) that is homologous to the helix-hairpin-helix (HhH) DNA repair enzymes. Here, w...

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Veröffentlicht in:	Journal of molecular biology 2002-01, Vol.315 (3), p.373-384
Hauptverfasser:	Mol, Clifford D, Arvai, Andrew S, Begley, Thomas J, Cunningham, Richard P, Tainer, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Pair Mismatch - genetics base twisting Binding Sites Carbon-Oxygen Lyases - chemistry Carbon-Oxygen Lyases - metabolism Crystallography, X-Ray Deoxyribonuclease (Pyrimidine Dimer) DNA - chemistry DNA - genetics DNA - metabolism DNA glycosylase DNA mismatch DNA repair DNA Repair - genetics DNA-(Apurinic or Apyrimidinic Site) Lyase DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endodeoxyribonucleases - chemistry Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Methanobacteriaceae - enzymology Methanobacteriaceae - genetics methylation Models, Molecular Molecular Sequence Data Mutation - genetics Nucleic Acid Conformation Nucleotides - chemistry Nucleotides - genetics Nucleotides - metabolism Protein Structure, Secondary Protein Structure, Tertiary Sequence Alignment Sequence Homology, Amino Acid Structure-Activity Relationship Thermodynamics Thymine - metabolism thymine-DNA glycosylase
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