Early and Late Outcomes of Thoracic Aortic Surgery in Hemodialysis Patients
Background The number of cardiovascular surgeries among hemodialysis patients is increasing according to the growing population of hemodialysis patients; however, the clinical outcome has not yet been clarified, especially in thoracic aortic surgery. The purpose of this study was to assess the early...
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Veröffentlicht in: | The Annals of thoracic surgery 2016-10, Vol.102 (4), p.1282-1288 |
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creator | Hibino, Makoto, MD Oshima, Hideki, MD, PhD Narita, Yuji, MD, PhD Abe, Tomonobu, MD, PhD Mutsuga, Masato, MD, PhD Fujimoto, Kazuro L., MD, PhD Tokuda, Yoshiyuki, MD, PhD Terazawa, Sachie, MD, PhD Ito, Hideki, MD, PhD Usui, Akihiko, MD, PhD |
description | Background The number of cardiovascular surgeries among hemodialysis patients is increasing according to the growing population of hemodialysis patients; however, the clinical outcome has not yet been clarified, especially in thoracic aortic surgery. The purpose of this study was to assess the early and late outcomes of thoracic aortic surgery in hemodialysis patients. Methods We retrospectively analyzed the outcomes of 700 consecutive open thoracic aortic surgeries from 2002 to 2014. We identified 21 patients receiving preoperative hemodialysis (group HD) and 679 patients not receiving preoperative hemodialysis (group N). The patients were predominantly male, had diabetes mellitus and cardiogenic shock, and had less hyperlipidemia and elective surgery in group HD. The early and late outcomes were compared between 21 patients in each group using a propensity-score matched analysis. Results The hospital stay and intensive care unit stay were significantly longer in group HD even after matching. The 30-day mortality and inhospital mortality showed no significant differences, whereas the rate of postoperative pneumonia was significantly higher in group HD compared with the matched group N ( p = 0.0067). The 1-year, 3-year, and 7-year survival rates in group HD were 73.4%, 45.7%, and 30.5%, respectively, which were significantly poorer than that of group N both in the prematched ( p < 0.001) and matched analyses ( p = 0.0027). Conclusions Considering the various operative risks associated with hemodialysis patients, the early mortality rate is acceptable, even after the association with many respiratory complications. Although hemodialysis patients have a compromised prognosis after surgery, excessive hesitation to perform thoracic aortic surgery may be avoided. |
doi_str_mv | 10.1016/j.athoracsur.2016.03.073 |
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The purpose of this study was to assess the early and late outcomes of thoracic aortic surgery in hemodialysis patients. Methods We retrospectively analyzed the outcomes of 700 consecutive open thoracic aortic surgeries from 2002 to 2014. We identified 21 patients receiving preoperative hemodialysis (group HD) and 679 patients not receiving preoperative hemodialysis (group N). The patients were predominantly male, had diabetes mellitus and cardiogenic shock, and had less hyperlipidemia and elective surgery in group HD. The early and late outcomes were compared between 21 patients in each group using a propensity-score matched analysis. Results The hospital stay and intensive care unit stay were significantly longer in group HD even after matching. The 30-day mortality and inhospital mortality showed no significant differences, whereas the rate of postoperative pneumonia was significantly higher in group HD compared with the matched group N ( p = 0.0067). The 1-year, 3-year, and 7-year survival rates in group HD were 73.4%, 45.7%, and 30.5%, respectively, which were significantly poorer than that of group N both in the prematched ( p < 0.001) and matched analyses ( p = 0.0027). Conclusions Considering the various operative risks associated with hemodialysis patients, the early mortality rate is acceptable, even after the association with many respiratory complications. Although hemodialysis patients have a compromised prognosis after surgery, excessive hesitation to perform thoracic aortic surgery may be avoided.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2016.03.073</identifier><identifier>PMID: 27234577</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Aged ; Aortic Aneurysm, Thoracic - mortality ; Aortic Aneurysm, Thoracic - surgery ; Cardiothoracic Surgery ; Cause of Death ; Cohort Studies ; Female ; Follow-Up Studies ; Hospital Mortality - trends ; Humans ; Kaplan-Meier Estimate ; Length of Stay ; Male ; Middle Aged ; Postoperative Complications - mortality ; Postoperative Complications - physiopathology ; Propensity Score ; Renal Dialysis - adverse effects ; Retrospective Studies ; Risk Assessment ; Statistics, Nonparametric ; Surgery ; Survival Rate ; Thoracic Surgical Procedures - methods ; Thoracic Surgical Procedures - mortality ; Time Factors ; Treatment Outcome</subject><ispartof>The Annals of thoracic surgery, 2016-10, Vol.102 (4), p.1282-1288</ispartof><rights>The Society of Thoracic Surgeons</rights><rights>2016 The Society of Thoracic Surgeons</rights><rights>Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-c32b17ca989026855602ba8bf81e32f2bf979c6d8bfd0afd8fb1a4a5f0a0eae43</citedby><cites>FETCH-LOGICAL-c545t-c32b17ca989026855602ba8bf81e32f2bf979c6d8bfd0afd8fb1a4a5f0a0eae43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.athoracsur.2016.03.073$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27234577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hibino, Makoto, MD</creatorcontrib><creatorcontrib>Oshima, Hideki, MD, PhD</creatorcontrib><creatorcontrib>Narita, Yuji, MD, PhD</creatorcontrib><creatorcontrib>Abe, Tomonobu, MD, PhD</creatorcontrib><creatorcontrib>Mutsuga, Masato, MD, PhD</creatorcontrib><creatorcontrib>Fujimoto, Kazuro L., MD, PhD</creatorcontrib><creatorcontrib>Tokuda, Yoshiyuki, MD, PhD</creatorcontrib><creatorcontrib>Terazawa, Sachie, MD, PhD</creatorcontrib><creatorcontrib>Ito, Hideki, MD, PhD</creatorcontrib><creatorcontrib>Usui, Akihiko, MD, PhD</creatorcontrib><title>Early and Late Outcomes of Thoracic Aortic Surgery in Hemodialysis Patients</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Background The number of cardiovascular surgeries among hemodialysis patients is increasing according to the growing population of hemodialysis patients; however, the clinical outcome has not yet been clarified, especially in thoracic aortic surgery. The purpose of this study was to assess the early and late outcomes of thoracic aortic surgery in hemodialysis patients. Methods We retrospectively analyzed the outcomes of 700 consecutive open thoracic aortic surgeries from 2002 to 2014. We identified 21 patients receiving preoperative hemodialysis (group HD) and 679 patients not receiving preoperative hemodialysis (group N). The patients were predominantly male, had diabetes mellitus and cardiogenic shock, and had less hyperlipidemia and elective surgery in group HD. The early and late outcomes were compared between 21 patients in each group using a propensity-score matched analysis. Results The hospital stay and intensive care unit stay were significantly longer in group HD even after matching. The 30-day mortality and inhospital mortality showed no significant differences, whereas the rate of postoperative pneumonia was significantly higher in group HD compared with the matched group N ( p = 0.0067). The 1-year, 3-year, and 7-year survival rates in group HD were 73.4%, 45.7%, and 30.5%, respectively, which were significantly poorer than that of group N both in the prematched ( p < 0.001) and matched analyses ( p = 0.0027). Conclusions Considering the various operative risks associated with hemodialysis patients, the early mortality rate is acceptable, even after the association with many respiratory complications. Although hemodialysis patients have a compromised prognosis after surgery, excessive hesitation to perform thoracic aortic surgery may be avoided.</description><subject>Adult</subject><subject>Aged</subject><subject>Aortic Aneurysm, Thoracic - mortality</subject><subject>Aortic Aneurysm, Thoracic - surgery</subject><subject>Cardiothoracic Surgery</subject><subject>Cause of Death</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hospital Mortality - trends</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Postoperative Complications - mortality</subject><subject>Postoperative Complications - physiopathology</subject><subject>Propensity Score</subject><subject>Renal Dialysis - adverse effects</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Statistics, Nonparametric</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Thoracic Surgical Procedures - methods</subject><subject>Thoracic Surgical Procedures - mortality</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi1ERZe2fwH5yCXBH3E-LkilKrRipSK1nK2JMy5ekrjYDlL-PV62LRKnnkYz8868mmcIoZyVnPH6w66E9MMHMHEJpciVksmSNfIV2XClRFEL1b0mG8aYLKquUcfkbYy7nIrcfkOORSNkpZpmQ75eQhhXCvNAt5CQ3izJ-Akj9Zbe_bVwhp77kHK4XcI9hpW6mV7h5AcH4xpdpN8gOZxTPCVHFsaIZ4_xhHz_fHl3cVVsb75cX5xvC6MqlQojRc8bA13bMVG3StVM9ND2tuUohRW97ZrO1EOuDAzs0NqeQwXKMmAIWMkT8v6w9yH4XwvGpCcXDY4jzOiXqHkrBOeikipL24PUBB9jQKsfgpsgrJozvUepd_ofSr1HqZnUGWUefffosvQTDs-DT-yy4NNBgPnW3w6DjiZzMDi4gCbpwbuXuHz8b4kZ3ewMjD9xxbjzS5gzS811FJrp2_1L9x_ltWSCKSn_AOsen6U</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Hibino, Makoto, MD</creator><creator>Oshima, Hideki, MD, PhD</creator><creator>Narita, Yuji, MD, PhD</creator><creator>Abe, Tomonobu, MD, PhD</creator><creator>Mutsuga, Masato, MD, PhD</creator><creator>Fujimoto, Kazuro L., MD, PhD</creator><creator>Tokuda, Yoshiyuki, MD, PhD</creator><creator>Terazawa, Sachie, MD, PhD</creator><creator>Ito, Hideki, MD, PhD</creator><creator>Usui, Akihiko, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Early and Late Outcomes of Thoracic Aortic Surgery in Hemodialysis Patients</title><author>Hibino, Makoto, MD ; Oshima, Hideki, MD, PhD ; Narita, Yuji, MD, PhD ; Abe, Tomonobu, MD, PhD ; Mutsuga, Masato, MD, PhD ; Fujimoto, Kazuro L., MD, PhD ; Tokuda, Yoshiyuki, MD, PhD ; Terazawa, Sachie, MD, PhD ; Ito, Hideki, MD, PhD ; Usui, Akihiko, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-c32b17ca989026855602ba8bf81e32f2bf979c6d8bfd0afd8fb1a4a5f0a0eae43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aortic Aneurysm, Thoracic - mortality</topic><topic>Aortic Aneurysm, Thoracic - surgery</topic><topic>Cardiothoracic Surgery</topic><topic>Cause of Death</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hospital Mortality - trends</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Postoperative Complications - mortality</topic><topic>Postoperative Complications - physiopathology</topic><topic>Propensity Score</topic><topic>Renal Dialysis - adverse effects</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Statistics, Nonparametric</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Thoracic Surgical Procedures - methods</topic><topic>Thoracic Surgical Procedures - mortality</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hibino, Makoto, MD</creatorcontrib><creatorcontrib>Oshima, Hideki, MD, PhD</creatorcontrib><creatorcontrib>Narita, Yuji, MD, PhD</creatorcontrib><creatorcontrib>Abe, Tomonobu, MD, PhD</creatorcontrib><creatorcontrib>Mutsuga, Masato, MD, PhD</creatorcontrib><creatorcontrib>Fujimoto, Kazuro L., MD, PhD</creatorcontrib><creatorcontrib>Tokuda, Yoshiyuki, MD, PhD</creatorcontrib><creatorcontrib>Terazawa, Sachie, MD, PhD</creatorcontrib><creatorcontrib>Ito, Hideki, MD, PhD</creatorcontrib><creatorcontrib>Usui, Akihiko, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hibino, Makoto, MD</au><au>Oshima, Hideki, MD, PhD</au><au>Narita, Yuji, MD, PhD</au><au>Abe, Tomonobu, MD, PhD</au><au>Mutsuga, Masato, MD, PhD</au><au>Fujimoto, Kazuro L., MD, PhD</au><au>Tokuda, Yoshiyuki, MD, PhD</au><au>Terazawa, Sachie, MD, PhD</au><au>Ito, Hideki, MD, PhD</au><au>Usui, Akihiko, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early and Late Outcomes of Thoracic Aortic Surgery in Hemodialysis Patients</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>102</volume><issue>4</issue><spage>1282</spage><epage>1288</epage><pages>1282-1288</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>Background The number of cardiovascular surgeries among hemodialysis patients is increasing according to the growing population of hemodialysis patients; however, the clinical outcome has not yet been clarified, especially in thoracic aortic surgery. The purpose of this study was to assess the early and late outcomes of thoracic aortic surgery in hemodialysis patients. Methods We retrospectively analyzed the outcomes of 700 consecutive open thoracic aortic surgeries from 2002 to 2014. We identified 21 patients receiving preoperative hemodialysis (group HD) and 679 patients not receiving preoperative hemodialysis (group N). The patients were predominantly male, had diabetes mellitus and cardiogenic shock, and had less hyperlipidemia and elective surgery in group HD. The early and late outcomes were compared between 21 patients in each group using a propensity-score matched analysis. Results The hospital stay and intensive care unit stay were significantly longer in group HD even after matching. The 30-day mortality and inhospital mortality showed no significant differences, whereas the rate of postoperative pneumonia was significantly higher in group HD compared with the matched group N ( p = 0.0067). The 1-year, 3-year, and 7-year survival rates in group HD were 73.4%, 45.7%, and 30.5%, respectively, which were significantly poorer than that of group N both in the prematched ( p < 0.001) and matched analyses ( p = 0.0027). Conclusions Considering the various operative risks associated with hemodialysis patients, the early mortality rate is acceptable, even after the association with many respiratory complications. Although hemodialysis patients have a compromised prognosis after surgery, excessive hesitation to perform thoracic aortic surgery may be avoided.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>27234577</pmid><doi>10.1016/j.athoracsur.2016.03.073</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Aortic Aneurysm, Thoracic - mortality Aortic Aneurysm, Thoracic - surgery Cardiothoracic Surgery Cause of Death Cohort Studies Female Follow-Up Studies Hospital Mortality - trends Humans Kaplan-Meier Estimate Length of Stay Male Middle Aged Postoperative Complications - mortality Postoperative Complications - physiopathology Propensity Score Renal Dialysis - adverse effects Retrospective Studies Risk Assessment Statistics, Nonparametric Surgery Survival Rate Thoracic Surgical Procedures - methods Thoracic Surgical Procedures - mortality Time Factors Treatment Outcome |
title | Early and Late Outcomes of Thoracic Aortic Surgery in Hemodialysis Patients |
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