Glutathione peroxidase and viral replication: Implications for viral evolution and chemoprevention
It is likely that several of the biological effects of selenium are due to its effects on selenoprotein activity. While the effects of the anti‐oxidant selenoprotein glutathione peroxidase (GPx) on inhibiting HIV activation have been well documented, it is clear that increased expression of this enz...
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| Veröffentlicht in: | BioFactors (Oxford) 2001, Vol.14 (1-4), p.205-210 |
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| creator | Diamond, Alan M. Hu, Ya Jun Mansur, David B. |
| description | It is likely that several of the biological effects of selenium are due to its effects on selenoprotein activity. While the effects of the anti‐oxidant selenoprotein glutathione peroxidase (GPx) on inhibiting HIV activation have been well documented, it is clear that increased expression of this enzyme can stimulate the replication and subsequent appearance of cytopathic effects associated with an acutely spreading HIV infection. The effects of GPx on both phases of the viral life cycle are likely mediated via its influence on signaling molecules that use reactive oxygen species, and similar influences on signaling pathways may account for some of the anti‐cancer effects of selenium. Similarly, selenium can alter mutagenesis rates in both viral genomes and the DNA of mammalian cells exposed to carcinogens. Comparisons between the effects of selenium and selenoproteins on viral infections and carcinogenesis may yield new insights into the mechanisms of action of this element. |
| doi_str_mv | 10.1002/biof.5520140126 |
| format | Article |
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While the effects of the anti‐oxidant selenoprotein glutathione peroxidase (GPx) on inhibiting HIV activation have been well documented, it is clear that increased expression of this enzyme can stimulate the replication and subsequent appearance of cytopathic effects associated with an acutely spreading HIV infection. The effects of GPx on both phases of the viral life cycle are likely mediated via its influence on signaling molecules that use reactive oxygen species, and similar influences on signaling pathways may account for some of the anti‐cancer effects of selenium. Similarly, selenium can alter mutagenesis rates in both viral genomes and the DNA of mammalian cells exposed to carcinogens. 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While the effects of the anti‐oxidant selenoprotein glutathione peroxidase (GPx) on inhibiting HIV activation have been well documented, it is clear that increased expression of this enzyme can stimulate the replication and subsequent appearance of cytopathic effects associated with an acutely spreading HIV infection. The effects of GPx on both phases of the viral life cycle are likely mediated via its influence on signaling molecules that use reactive oxygen species, and similar influences on signaling pathways may account for some of the anti‐cancer effects of selenium. Similarly, selenium can alter mutagenesis rates in both viral genomes and the DNA of mammalian cells exposed to carcinogens. Comparisons between the effects of selenium and selenoproteins on viral infections and carcinogenesis may yield new insights into the mechanisms of action of this element.</description><subject>Animals</subject><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Anticarcinogenic Agents - therapeutic use</subject><subject>Biological Evolution</subject><subject>Genome, Viral</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>HIV Infections - physiopathology</subject><subject>HIV Infections - prevention & control</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Mutagenesis</subject><subject>Neoplasms - prevention & control</subject><subject>Selenium - pharmacology</subject><subject>Selenium - therapeutic use</subject><subject>selenoproteins</subject><subject>Signal Transduction</subject><subject>Virus Physiological Phenomena</subject><subject>Virus Replication - physiology</subject><subject>Viruses - genetics</subject><issn>0951-6433</issn><issn>1872-8081</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEURa2qqATadXfVrLob8LPHY4euCoIQgcoi_VhaHvtZuMzEgz0J8O-ZkAjUVVdP7-rcs7iEfAZ6BJSy4yZEfyQEo1BRYPU7MgElWamogvdkQqcCyrrifJ8c5PyXUuC0Uh_IPoCoVSXUhDSzdjWY4TbEJRY9pvgYnMlYmKUr1iGZtkjYt8GaYSROinn3-uTCx7RjcB1HzRi-9OwtdrFPuMblJvtI9rxpM37a3UPy6-L859lleX0zm599vy5tBVVdAirPhJLGugq5w2k9dVBL5y2Al5Xi0DSKS954x5xzVhmceicEgrTSG8YPydett0_xfoV50F3IFtvWLDGusgbFGFCpRvB4C9oUc07odZ9CZ9KTBqo3s-rNrPpt1rHxZadeNR26N3634wh82wIPocWn__n06fzm4h99uW2HPODja9ukO11LLoX-82OmF_xq8XuhZvqSPwP4NJcv</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Diamond, Alan M.</creator><creator>Hu, Ya Jun</creator><creator>Mansur, David B.</creator><general>IOS Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>2001</creationdate><title>Glutathione peroxidase and viral replication: Implications for viral evolution and chemoprevention</title><author>Diamond, Alan M. ; Hu, Ya Jun ; Mansur, David B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4146-1e8f2587acd4e3de969d167dfc11f74831bb8373bfd2dddc8ae9fd55e17c7fa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Anticarcinogenic Agents - therapeutic use</topic><topic>Biological Evolution</topic><topic>Genome, Viral</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>HIV Infections - physiopathology</topic><topic>HIV Infections - prevention & control</topic><topic>HIV-1 - physiology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Mutagenesis</topic><topic>Neoplasms - prevention & control</topic><topic>Selenium - pharmacology</topic><topic>Selenium - therapeutic use</topic><topic>selenoproteins</topic><topic>Signal Transduction</topic><topic>Virus Physiological Phenomena</topic><topic>Virus Replication - physiology</topic><topic>Viruses - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diamond, Alan M.</creatorcontrib><creatorcontrib>Hu, Ya Jun</creatorcontrib><creatorcontrib>Mansur, David B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>BioFactors (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diamond, Alan M.</au><au>Hu, Ya Jun</au><au>Mansur, David B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione peroxidase and viral replication: Implications for viral evolution and chemoprevention</atitle><jtitle>BioFactors (Oxford)</jtitle><addtitle>BioFactors</addtitle><date>2001</date><risdate>2001</risdate><volume>14</volume><issue>1-4</issue><spage>205</spage><epage>210</epage><pages>205-210</pages><issn>0951-6433</issn><eissn>1872-8081</eissn><abstract>It is likely that several of the biological effects of selenium are due to its effects on selenoprotein activity. 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Comparisons between the effects of selenium and selenoproteins on viral infections and carcinogenesis may yield new insights into the mechanisms of action of this element.</abstract><cop>Amsterdam</cop><pub>IOS Press</pub><pmid>11568458</pmid><doi>10.1002/biof.5520140126</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Anticarcinogenic Agents - pharmacology Anticarcinogenic Agents - therapeutic use Biological Evolution Genome, Viral Glutathione Peroxidase - metabolism HIV Infections - physiopathology HIV Infections - prevention & control HIV-1 - physiology Human immunodeficiency virus Humans Mutagenesis Neoplasms - prevention & control Selenium - pharmacology Selenium - therapeutic use selenoproteins Signal Transduction Virus Physiological Phenomena Virus Replication - physiology Viruses - genetics |
| title | Glutathione peroxidase and viral replication: Implications for viral evolution and chemoprevention |
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