Expression of the oncogenic NPM-ALK chimeric protein in human lymphoid T-cells inhibits drug-induced, but not Fas-induced apoptosis

Anaplastic large cell lymphomas (ALCLs) are frequently associated with the t(2;5)(p23;q35) translocation, leading to the expression of NPM-ALK, a fusion protein linking nucleophosmin and anaplastic lymphoma kinase, a receptor tyrosine kinase. In ALCLs, dimerization of NPM-ALK leads to constitutive a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2001-11, Vol.20 (50), p.7386-7397
Hauptverfasser:	GREENLAND, Catherine, TOURIOL, Christian, CHEVILLARD, Grégory, MORRIS, Stephan W, RENYUAN BAI, DUYSTER, Justus, DELSOL, Georges, ALLOUCHE, Michèle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Ageing, cell death AKT protein ALK protein Annexin V Anthracyclines Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Apoptosis - physiology Binding Sites Biological and medical sciences Cell physiology Cells Chromones - pharmacology Cytochrome c Cytochrome c Group - metabolism Cytology Cytoplasm Cytosol Dimerization Doxorubicin Doxorubicin - pharmacology Enzyme Inhibitors - pharmacology Etoposide Etoposide - pharmacology Fas antigen Fas Ligand Protein fas Receptor - physiology Fundamental and applied biological sciences. Psychology Fusion protein Growth factors Humans Immunocytochemistry Isoenzymes - metabolism Jurkat Cells - drug effects Jurkat Cells - metabolism Kinases Lymphocytes T Lymphoma Lymphomas Membrane Glycoproteins - physiology Mitochondria Mitochondria - drug effects Mitochondria - enzymology Mitogenicity Molecular and cellular biology Morpholines - pharmacology Mutagenesis, Site-Directed Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology NPM protein Nucleoli Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Phospholipase C Phospholipase C gamma Phosphorylation Phosphotransferases Protein Processing, Post-Translational Protein-Serine-Threonine Kinases Protein-tyrosine kinase receptors Protein-Tyrosine Kinases - biosynthesis Protein-Tyrosine Kinases - chemistry Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - physiology Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Recombinant Fusion Proteins - physiology T cells T-Lymphocytes - drug effects T-Lymphocytes - metabolism Transfection Type C Phospholipases - metabolism Tyrosine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!