Expression of Novel ING Variants Is Regulated by Thyroid Hormone in the Xenopus laevis Tadpole

The candidate tumor suppressor gene,ING1, encodes several protein isoforms as a result of alternative splicing that may possess agonistic and antagonistic roles in the control of cell proliferation and apoptosis. Recently a related gene, ING2, was isolated in human whose expression is increased in a...

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Veröffentlicht in:	The Journal of biological chemistry 2001-12, Vol.276 (50), p.47013-47020
Hauptverfasser:	Wagner, Mary J., Gogela-Spehar, Markéta, Skirrow, Rachel C., Johnston, Randal N., Riabowol, Karl, Helbing, Caren C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Animals Apoptosis Base Sequence Blotting, Northern Blotting, Western Cell Differentiation Cell Division Cell Lineage Cell Nucleus - metabolism Cloning, Molecular Culture Media, Serum-Free - pharmacology DNA, Complementary - metabolism Female Freshwater Gene Library Genes, Tumor Suppressor Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Humans ING1 gene ING2 gene Male Metamorphosis, Biological Mice Molecular Sequence Data Organ Culture Techniques Protein Isoforms Protein Structure, Tertiary Receptors, Cytoplasmic and Nuclear Receptors, Thyroid Hormone - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Sequence Homology, Amino Acid Signal Transduction Thyroid Hormones - metabolism Thyroid Hormones - pharmacology Tissue Distribution Triiodothyronine - pharmacology Tumor Suppressor Proteins Xenopus Xenopus laevis Xenopus Proteins
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