The hypnotic bromovalerylurea ameliorates 6-hydroxydopamine-induced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia

The low molecular weight organic compound bromovalerylurea (BU) has long been used as a hypnotic/sedative. In the present study, we found that BU suppressed mRNA expression of proinflammatory factors and nitric oxide release in lipopolysaccharide (LPS)-treated rat primary microglial cell cultures. B...

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Veröffentlicht in:	Neurochemistry international 2016-10, Vol.99, p.158-168
Hauptverfasser:	Higaki, Hiromi, Choudhury, Mohammed Emamussalehin, Kawamoto, Chisato, Miyamoto, Keisuke, Islam, Afsana, Ishii, Yurika, Miyanishi, Kazuya, Takeda, Haruna, Seo, Naoto, Sugimoto, Kana, Takahashi, Hisaaki, Yano, Hajime, Tanaka, Junya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bromisovalum - pharmacology Cells, Cultured Coculture Techniques Cytokine Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Dose-Response Relationship, Drug Gene Expression Hypnotics and Sedatives - pharmacology Interferon Regulatory Factors - antagonists & inhibitors Interferon Regulatory Factors - biosynthesis Interferon Regulatory Factors - genetics IRF Male Microglia - drug effects Microglia - metabolism Neuroprotective factors Oxidopamine - toxicity Parkinson Proinflammatory Rats Rats, Wistar
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