Profound astrogenesis in the striatum of adult mice following nigrostriatal dopaminergic lesion by repeated MPTP administration

Neural progenitor cells are present in the rodent brain throughout adulthood, and can proliferate and differentiate into new neurons and/or glia to repair injury. To explore the repair processes mediated by brain progenitor cells, a selective lesion of the nigrostriatal dopaminergic pathway was indu...

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Veröffentlicht in:	Brain research. Developmental brain research 2001-11, Vol.131 (1), p.57-65
Hauptverfasser:	Mao, Limin, Lau, Yuen-Sum, Petroske, Elizabeth, Wang, John Q
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology 3,4-Dihydroxyphenylacetic Acid - metabolism Age Factors Animals Astrocytes - chemistry Astrocytes - metabolism Astrocytes - pathology BrdU Bromodeoxyuridine - analysis Caudate putamen Cell Differentiation - drug effects Cell Division - drug effects Cell Survival - drug effects Dopamine - metabolism Dopamine Agents - pharmacology Male Mice Mice, Inbred C57BL MPTP Poisoning - pathology Neostriatum - pathology Neurogenesis Precursor Stem cell Stem Cells - chemistry Stem Cells - metabolism Stem Cells - pathology Substantia nigra Substantia Nigra - pathology Tyrosine 3-Monooxygenase - metabolism
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