Developmental Regulation of Heat Shock Protein 83 in Leishmania: 3' Processing and mRNA Stability Control Transcript Abundance, and Translation is Directed by a Determinant in the 3'-Untranslated Region

Developmental gene regulation in trypanosomatids proceeds exclusively by post-transcriptional mechanisms. Stability and abundance of heat shock protein (HSP)70 and HSP83 transcripts in Leishmania increase at mammalian-like temperatures, and their translation is enhanced. Here we report that the 3�...

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Veröffentlicht in:The Journal of biological chemistry 2001-12, Vol.276 (51), p.47922-47929
Hauptverfasser: Zilka, A, Garlapati, S, Dahan, E, Yaolsky, V, Shapira, M
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Sprache:eng
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