A role for c-myc in DNA damage-induced apoptosis in a human TP53-mutant small-cell lung cancer cell line

Based on the role of p53 in the control of apoptosis following DNA damage, the status of the TP53 gene has been implicated as a major determinant of tumour responsiveness to cytotoxic therapies. In spite of the high frequency of TP53 mutations, small-cell lung cancer (SCLC) is recognised as one of t...

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Veröffentlicht in:	European journal of cancer (1990) 2001-11, Vol.37 (17), p.2247-2256
Hauptverfasser:	Supino, R, Perego, P, Gatti, L, Caserini, C, Leonetti, C, Colantuono, M, Zuco, V, Carenini, N, Zupi, G, Zunino, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis - genetics Apoptosis - radiation effects Biological and medical sciences c-myc c-myc gene Carcinoma, Small Cell - genetics Carcinoma, Small Cell - metabolism Cell Cycle - drug effects Cell Cycle - radiation effects Cyclin-Dependent Kinase Inhibitor p21 Cyclins - metabolism DNA damage DNA Damage - genetics DNA, Neoplasm - genetics Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Doxorubicin - pharmacology Gamma Rays Gene Expression Regulation, Neoplastic - drug effects Genes, p53 Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Medical sciences Mutation Neoplasm Proteins - metabolism Pneumology Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Small-cell lung cancer TP53-mutation Tumor Cells, Cultured Tumor Suppressor Protein p53 - metabolism Tumors of the respiratory system and mediastinum
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