Resolution of α-Hydroxytamoxifen; R-Isomer Forms More DNA Adducts in Rat Liver Cells

The genotoxic tamoxifen metabolite α-hydroxytamoxifen has been resolved into R- and S-enantiomers. This was achieved by preparing its ester with S-camphanic acid, chromatographic separation into two diastereoisomers, and hydrolysis to give (+)- and (−)-α-hydroxytamoxifen. The configuration of the (−...

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