P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts

We previously reported that transcription-coupled repair (TCR)-deficient human fibroblasts are extremely sensitive to UV-induced apoptosis and this sensitivity correlated with the induction of the p53 tumour suppressor. However, we have also found that p53 can be protective against UV-induced apopto...

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Veröffentlicht in:	Oncogene 2001-10, Vol.20 (46), p.6805-6808
Hauptverfasser:	MCKAY, Bruce C, BECERRIL, Cecilia, LJUNGMAN, Mats
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Apoptosis Biological and medical sciences Cancer therapies Cell physiology Cisplatin Cisplatin - pharmacology Cockayne syndrome Cockayne Syndrome - metabolism Cockayne Syndrome - pathology DNA damage DNA Repair Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Fibroblasts Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Human papillomavirus Humans Molecular and cellular biology Oncogene Proteins, Viral - metabolism p53 Protein Radiation-Sensitizing Agents - pharmacology Repressor Proteins RNA polymerase RNA, Messenger - metabolism Transcription Transcription, Genetic Transcription-coupled repair Tumor suppressor genes Tumor Suppressor Protein p53 - metabolism Tumors Ultraviolet radiation Ultraviolet Rays Xeroderma pigmentosum Xeroderma Pigmentosum - metabolism Xeroderma Pigmentosum - pathology
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