Bone morphogenetic protein 2 / SMAD signalling in human ligamentocytes of degenerated and aged anterior cruciate ligaments

Abstract Objective Anterior cruciate ligament (ACL) degeneration leads to knee instability and favours osteoarthritis (OA) progression. During ageing the growth factor sensitivity of ligaments changes but nothing is known about BMP2-signalling and -sensitivity in degenerated ACLs. This study address...

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Veröffentlicht in:	Osteoarthritis and cartilage 2016-10, Vol.24 (10), p.1816-1825
Hauptverfasser:	Ruschke, Karen, Meier, Carola, Ullah, Mujib, Michaela Krebs, Anna-Catharina, Silberreis, Kim, Kohl, Benjamin, Knaus, Petra, Jagielski, Michal, Arens, Stephan, Schulze-Tanzil, Gundula, VMD
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing Anterior Cruciate Ligament Anterior cruciate ligament degeneration BMP2 signalling Bone Morphogenetic Protein 2 Chondrogenesis Female Fibroblasts Humans Ligament fibroblasts Male Middle Aged Osteoarthritis Phospho SMAD Rheumatology
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