Alteration of radiation-induced hematotoxicity by amifostine
To investigate whether amifostine can reduce radiation hematotoxicity. Seventy-three patients undergoing radiotherapy for squamous cell carcinoma of the head and neck at the university clinics of Freiburg, Heidelberg, and Erlangen were evaluated. All received 60 Gy (50-70 Gy) at 5 x 2 Gy fractions p...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2001-11, Vol.51 (4), p.947-951 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | MOMM, Felix BECHTOLD, Christine RUDAT, Volker STRNAD, Vratislav TSEKOS, Alexander FISCHER, Karin HENKE, Michael |
| description | To investigate whether amifostine can reduce radiation hematotoxicity.
Seventy-three patients undergoing radiotherapy for squamous cell carcinoma of the head and neck at the university clinics of Freiburg, Heidelberg, and Erlangen were evaluated. All received 60 Gy (50-70 Gy) at 5 x 2 Gy fractions per week employing standard techniques. Thirty-five were randomized to receive 200 mg/m(2) amifostine i.v. 30 min before radiation; 38 served as control patients. Blood counts (total n = 501) were determined before, during, and while completing radiotherapy. Changes of leukocyte, platelet, and hemoglobin levels were determined and compared using the t test.
The blood hemoglobin level and the platelet count were not affected by irradiation, for either the amifostine-treated or control patients. Similarly, the leukocyte counts of amifostine-treated patients did not change during irradiation. However, control patients experienced a decrease in leukocyte count from 8.1 x 10(3)/mm(3) to 5.8 x 10(3)/mm(3) (difference: 2.3 x 10(3)/mm(3)). This seems to be line specific: Whereas amifostine does not affect lymphocyte count, a radiation-induced decrease of neutrophil granulocytes seems to be prevented.
Amifostine protects from radiation hematotoxicity, particularly affecting the granulocytopoiesis. These data confirm results from our former study. |
| doi_str_mv | 10.1016/s0360-3016(01)01710-2 |
| format | Article |
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Seventy-three patients undergoing radiotherapy for squamous cell carcinoma of the head and neck at the university clinics of Freiburg, Heidelberg, and Erlangen were evaluated. All received 60 Gy (50-70 Gy) at 5 x 2 Gy fractions per week employing standard techniques. Thirty-five were randomized to receive 200 mg/m(2) amifostine i.v. 30 min before radiation; 38 served as control patients. Blood counts (total n = 501) were determined before, during, and while completing radiotherapy. Changes of leukocyte, platelet, and hemoglobin levels were determined and compared using the t test.
The blood hemoglobin level and the platelet count were not affected by irradiation, for either the amifostine-treated or control patients. Similarly, the leukocyte counts of amifostine-treated patients did not change during irradiation. However, control patients experienced a decrease in leukocyte count from 8.1 x 10(3)/mm(3) to 5.8 x 10(3)/mm(3) (difference: 2.3 x 10(3)/mm(3)). This seems to be line specific: Whereas amifostine does not affect lymphocyte count, a radiation-induced decrease of neutrophil granulocytes seems to be prevented.
Amifostine protects from radiation hematotoxicity, particularly affecting the granulocytopoiesis. These data confirm results from our former study.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/s0360-3016(01)01710-2</identifier><identifier>PMID: 11704315</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>amifostine ; Amifostine - therapeutic use ; Biological and medical sciences ; Blood Platelets - drug effects ; Blood Platelets - radiation effects ; Blood. Blood coagulation. Reticuloendothelial system ; Carcinoma, Squamous Cell - blood ; Carcinoma, Squamous Cell - radiotherapy ; Granulocytes - drug effects ; Granulocytes - radiation effects ; Head and Neck Neoplasms - blood ; Head and Neck Neoplasms - radiotherapy ; Hemoglobin A - analysis ; Hemoglobin A - drug effects ; Hemoglobin A - radiation effects ; Humans ; Leukocyte Count ; Leukocytes - drug effects ; Leukocytes - radiation effects ; Lymphocytes - drug effects ; Lymphocytes - radiation effects ; Medical sciences ; Pharmacology. Drug treatments ; Platelet Count ; Prospective Studies ; Radiation Protection ; Radiation-Protective Agents - therapeutic use ; radiotherapy ; Radiotherapy Dosage</subject><ispartof>International journal of radiation oncology, biology, physics, 2001-11, Vol.51 (4), p.947-951</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-da2be4505c08eb80f5c4e15c5c1893fa48971127b042f5dea3945c738fd573493</citedby><cites>FETCH-LOGICAL-c432t-da2be4505c08eb80f5c4e15c5c1893fa48971127b042f5dea3945c738fd573493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14104078$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11704315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MOMM, Felix</creatorcontrib><creatorcontrib>BECHTOLD, Christine</creatorcontrib><creatorcontrib>RUDAT, Volker</creatorcontrib><creatorcontrib>STRNAD, Vratislav</creatorcontrib><creatorcontrib>TSEKOS, Alexander</creatorcontrib><creatorcontrib>FISCHER, Karin</creatorcontrib><creatorcontrib>HENKE, Michael</creatorcontrib><title>Alteration of radiation-induced hematotoxicity by amifostine</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>To investigate whether amifostine can reduce radiation hematotoxicity.
Seventy-three patients undergoing radiotherapy for squamous cell carcinoma of the head and neck at the university clinics of Freiburg, Heidelberg, and Erlangen were evaluated. All received 60 Gy (50-70 Gy) at 5 x 2 Gy fractions per week employing standard techniques. Thirty-five were randomized to receive 200 mg/m(2) amifostine i.v. 30 min before radiation; 38 served as control patients. Blood counts (total n = 501) were determined before, during, and while completing radiotherapy. Changes of leukocyte, platelet, and hemoglobin levels were determined and compared using the t test.
The blood hemoglobin level and the platelet count were not affected by irradiation, for either the amifostine-treated or control patients. Similarly, the leukocyte counts of amifostine-treated patients did not change during irradiation. However, control patients experienced a decrease in leukocyte count from 8.1 x 10(3)/mm(3) to 5.8 x 10(3)/mm(3) (difference: 2.3 x 10(3)/mm(3)). This seems to be line specific: Whereas amifostine does not affect lymphocyte count, a radiation-induced decrease of neutrophil granulocytes seems to be prevented.
Amifostine protects from radiation hematotoxicity, particularly affecting the granulocytopoiesis. These data confirm results from our former study.</description><subject>amifostine</subject><subject>Amifostine - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - radiation effects</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Granulocytes - drug effects</subject><subject>Granulocytes - radiation effects</subject><subject>Head and Neck Neoplasms - blood</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Hemoglobin A - analysis</subject><subject>Hemoglobin A - drug effects</subject><subject>Hemoglobin A - radiation effects</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Leukocytes - drug effects</subject><subject>Leukocytes - radiation effects</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - radiation effects</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet Count</subject><subject>Prospective Studies</subject><subject>Radiation Protection</subject><subject>Radiation-Protective Agents - therapeutic use</subject><subject>radiotherapy</subject><subject>Radiotherapy Dosage</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQhoMotlZ_grIXRQ-rM5ukmwUvpfgFBQ8qeAvZbIKR_ahJFuy_d_uBPb0z8Lwz8BByjnCLgNO7AHQKKR3Ga8AbwBwhzQ7IGEVepJTzz0My_kdG5CSEbwBAzNkxGQ0BjCIfk_tZHY1X0XVt0tnEq8ptltS1Va9NlXyZRsUudr9Ou7hKylWiGme7EF1rTsmRVXUwZ7uckI_Hh_f5c7p4fXqZzxapZjSLaaWy0jAOXIMwpQDLNTPINdcoCmoVE0WOmOUlsMzyyihaMK5zKmzFc8oKOiFX27tL3_30JkTZuKBNXavWdH2QKDIouKADyLeg9l0I3li59K5RfiUR5FqbfFs7kWsnElButMls6F3sHvRlY6p9a-dpAC53gApa1darVruw5xgCg1zQPwOkdNc</recordid><startdate>20011115</startdate><enddate>20011115</enddate><creator>MOMM, Felix</creator><creator>BECHTOLD, Christine</creator><creator>RUDAT, Volker</creator><creator>STRNAD, Vratislav</creator><creator>TSEKOS, Alexander</creator><creator>FISCHER, Karin</creator><creator>HENKE, Michael</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20011115</creationdate><title>Alteration of radiation-induced hematotoxicity by amifostine</title><author>MOMM, Felix ; BECHTOLD, Christine ; RUDAT, Volker ; STRNAD, Vratislav ; TSEKOS, Alexander ; FISCHER, Karin ; HENKE, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-da2be4505c08eb80f5c4e15c5c1893fa48971127b042f5dea3945c738fd573493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>amifostine</topic><topic>Amifostine - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - radiation effects</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Granulocytes - drug effects</topic><topic>Granulocytes - radiation effects</topic><topic>Head and Neck Neoplasms - blood</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Hemoglobin A - analysis</topic><topic>Hemoglobin A - drug effects</topic><topic>Hemoglobin A - radiation effects</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Leukocytes - drug effects</topic><topic>Leukocytes - radiation effects</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - radiation effects</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet Count</topic><topic>Prospective Studies</topic><topic>Radiation Protection</topic><topic>Radiation-Protective Agents - therapeutic use</topic><topic>radiotherapy</topic><topic>Radiotherapy Dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOMM, Felix</creatorcontrib><creatorcontrib>BECHTOLD, Christine</creatorcontrib><creatorcontrib>RUDAT, Volker</creatorcontrib><creatorcontrib>STRNAD, Vratislav</creatorcontrib><creatorcontrib>TSEKOS, Alexander</creatorcontrib><creatorcontrib>FISCHER, Karin</creatorcontrib><creatorcontrib>HENKE, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOMM, Felix</au><au>BECHTOLD, Christine</au><au>RUDAT, Volker</au><au>STRNAD, Vratislav</au><au>TSEKOS, Alexander</au><au>FISCHER, Karin</au><au>HENKE, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alteration of radiation-induced hematotoxicity by amifostine</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2001-11-15</date><risdate>2001</risdate><volume>51</volume><issue>4</issue><spage>947</spage><epage>951</epage><pages>947-951</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>To investigate whether amifostine can reduce radiation hematotoxicity.
Seventy-three patients undergoing radiotherapy for squamous cell carcinoma of the head and neck at the university clinics of Freiburg, Heidelberg, and Erlangen were evaluated. All received 60 Gy (50-70 Gy) at 5 x 2 Gy fractions per week employing standard techniques. Thirty-five were randomized to receive 200 mg/m(2) amifostine i.v. 30 min before radiation; 38 served as control patients. Blood counts (total n = 501) were determined before, during, and while completing radiotherapy. Changes of leukocyte, platelet, and hemoglobin levels were determined and compared using the t test.
The blood hemoglobin level and the platelet count were not affected by irradiation, for either the amifostine-treated or control patients. Similarly, the leukocyte counts of amifostine-treated patients did not change during irradiation. However, control patients experienced a decrease in leukocyte count from 8.1 x 10(3)/mm(3) to 5.8 x 10(3)/mm(3) (difference: 2.3 x 10(3)/mm(3)). This seems to be line specific: Whereas amifostine does not affect lymphocyte count, a radiation-induced decrease of neutrophil granulocytes seems to be prevented.
Amifostine protects from radiation hematotoxicity, particularly affecting the granulocytopoiesis. These data confirm results from our former study.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>11704315</pmid><doi>10.1016/s0360-3016(01)01710-2</doi><tpages>5</tpages></addata></record> |
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| subjects | amifostine Amifostine - therapeutic use Biological and medical sciences Blood Platelets - drug effects Blood Platelets - radiation effects Blood. Blood coagulation. Reticuloendothelial system Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - radiotherapy Granulocytes - drug effects Granulocytes - radiation effects Head and Neck Neoplasms - blood Head and Neck Neoplasms - radiotherapy Hemoglobin A - analysis Hemoglobin A - drug effects Hemoglobin A - radiation effects Humans Leukocyte Count Leukocytes - drug effects Leukocytes - radiation effects Lymphocytes - drug effects Lymphocytes - radiation effects Medical sciences Pharmacology. Drug treatments Platelet Count Prospective Studies Radiation Protection Radiation-Protective Agents - therapeutic use radiotherapy Radiotherapy Dosage |
| title | Alteration of radiation-induced hematotoxicity by amifostine |
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