Water-soluble derivatives of 4-oxo-N-(4-hydroxyphenyl) retinamide: synthesis and biological activity

A novel series of 4‐oxo‐N‐(4‐hydroxyphenyl) retinamide (4‐oxo‐4‐HPR) derivatives were synthesized with the aim of increasing the poor solubility of the parent compound in biological fluids, while maintaining the cytotoxic activity and the dual mechanism of action. The most promising compound 13a sho...

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