Pharmacological Characterization of a Potent Inhibitor of Autotaxin in Animal Models of Inflammatory Bowel Disease and Multiple Sclerosis

Autotaxin is a secreted enzyme that catalyzes the conversion of lysophosphatidyl choline into the bioactive lipid mediator lysophosphatidic acid (LPA). It is the primary enzyme responsible for LPA production in plasma. It is upregulated in inflammatory conditions and inhibition of autotaxin may have...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2016-10, Vol.359 (1), p.207-214
Hauptverfasser:	Thirunavukkarasu, Kannan, Tan, Bailin, Swearingen, Craig A., Rocha, Guilherme, Bui, Hai H., McCann, Denis J., Jones, Spencer B., Norman, Bryan H., Pfeifer, Lance A., Saha, Joy K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Analgesics - administration & dosage Analgesics - pharmacokinetics Analgesics - pharmacology Analgesics - therapeutic use Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacokinetics Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biological Availability Disease Models, Animal Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacokinetics Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Female Inflammatory Bowel Diseases - drug therapy Male Mice Multiple Sclerosis - drug therapy Phosphoric Diester Hydrolases - metabolism Visceral Pain - drug therapy
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