Simulation of heterogeneous molecular delivery in tumours using μCT reconstructions and MRI validation

Utilizing the detailed vascular network obtained from micro-computed tomography (μCT) to establish a mathematical model of the temporal molecular distribution within a murine C3H mammary carcinoma. Female CDF1 mice with a C3H mammary carcinoma on the right rear foot were used in this study. Dynamic...

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Veröffentlicht in:	Microvascular research 2016-11, Vol.108, p.69-74
Hauptverfasser:	Wittenborn, Thomas Rea, Nielsen, Thomas, Thomsen, Jesper Skovhus, Horsman, Michael Robert, Nygaard, Jens Vinge
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models and imaging Animals Antigens, CD34 - metabolism Antineoplastic Agents - administration & dosage Antineoplastic Agents - metabolism Biological Transport Blood Vessels - diagnostic imaging Blood Vessels - metabolism Computed Tomography Angiography Computer Simulation Diffusion Female Finite Element Analysis Finite element modeling Immunohistochemistry Magnetic Resonance Imaging Magnetic resonance imaging (MRI) Mammary Neoplasms, Animal - blood supply Mammary Neoplasms, Animal - diagnostic imaging Mammary Neoplasms, Animal - drug therapy Mammary Neoplasms, Animal - metabolism Mice Models, Biological Molecular Diagnostic Techniques - methods Predictive Value of Tests Reproducibility of Results X-ray imaging and computed tomography X-Ray Microtomography
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