Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice

[Display omitted] Oxycodone has been used clinically for over 90 years. While it is known that it exhibits low affinity for the multiple opioid receptors, whether its pharmacological activities are due to oxycodone activation of the opioid receptor type or due to its active metabolite (oxymorphone)...

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Veröffentlicht in:	Pharmacological research 2016-09, Vol.111, p.867-876
Hauptverfasser:	Yang, Pao-Pao, Yeh, Geng-Chang, Yeh, Teng-Kuang, Xi, Jinghua, Loh, Horace H., Law, Ping-Yee, Tao, Pao-Luh
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacology Animals Antinociceptive Brain - drug effects Brain - metabolism Brain - physiopathology Disease Models, Animal Dose-Response Relationship, Drug Genotype Injections, Intraventricular Injections, Subcutaneous Male Mice, Inbred C57BL Mice, Knockout Narcotic Antagonists - pharmacology Nociception - drug effects Nociceptive Pain - genetics Nociceptive Pain - metabolism Nociceptive Pain - physiopathology Nociceptive Pain - prevention & control Opioid receptors Oxycodone Oxycodone - administration & dosage Oxycodone - pharmacology Oxymorphone Pain Threshold - drug effects Phenotype Receptors, Opioid, delta - agonists Receptors, Opioid, delta - metabolism Receptors, Opioid, mu - genetics Receptors, Opioid, mu - metabolism Signal Transduction - drug effects Time Factors
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