Effects of tongxinluo on angiogenesis in the carotid adventitia of hyperlipidemic rabbits

Atherosclerosis, as a common arterial disease with high morbidity rate, is reported to be closely associated with adventitia angiogenesis. The present study aimed to investigate the effect of tongxinluo (TXL) on angiogenesis in the carotid adventitia of hyperlipidemic rabbits and the underlying mech...

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Veröffentlicht in:	Molecular medicine reports 2016-10, Vol.14 (4), p.3832-3840
Hauptverfasser:	Zhou, Jianhua, Cao, Bingfeng, Ju, Weiping, Liu, Sen, Song, Jianguang, Liu, Lixia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adventitia - blood supply Adventitia - drug effects Adventitia - metabolism Adventitia - pathology Angiogenesis Angiogenesis Inhibitors - pharmacology Animals Arteriosclerosis Atherosclerosis Atorvastatin Cardiovascular disease Care and treatment Carotid arteries Carotid Arteries - drug effects Carotid Arteries - metabolism Carotid Arteries - pathology Chinese medicine Cholesterol Disease Models, Animal Drug dosages Drugs, Chinese Herbal - pharmacology FDA approval Feeds Fluorescence in situ hybridization Gene expression Gene Expression Regulation - drug effects Health aspects High cholesterol diet Hyperlipoproteinemias - blood Hyperlipoproteinemias - complications Laboratory animals Lipids Lipids - blood Male Medicine, Chinese Methods Morbidity NADPH Oxidases - analysis NADPH Oxidases - genetics Neovascularization Neovascularization, Pathologic - blood Neovascularization, Pathologic - complications Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Oxidative stress Pathogenesis Patient outcomes Polymerase chain reaction Proteins Rabbits Reactive oxygen species Reactive Oxygen Species - metabolism Reverse transcription Studies tongxinluo vasa vasorum Vascular endothelial growth factor Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - analysis Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular endothelial growth factor receptors Veins & arteries
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