Gender specific differences in oxidative stress and inflammatory signaling in healthy term neonates and their mothers
Background: Gender is a crucial determinant of life span, but little is known about gender differences in free radical homeostasis and inflammatory signaling. The aim of the study was to determine gender-related differences concerning oxidative stress and inflammatory signaling of healthy neonates a...
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| Veröffentlicht in: | Pediatric research 2016-10, Vol.80 (4), p.595-601 |
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| creator | Diaz-Castro, Javier Pulido-Moran, Mario Moreno-Fernandez, Jorge Kajarabille, Naroa de Paco, Catalina Garrido-Sanchez, Maria Prados, Sonia Ochoa, Julio J. |
| description | Background:
Gender is a crucial determinant of life span, but little is known about gender differences in free radical homeostasis and inflammatory signaling. The aim of the study was to determine gender-related differences concerning oxidative stress and inflammatory signaling of healthy neonates and mothers.
Methods:
Fifty-six mothers with normal gestational course and spontaneous delivery were selected. Blood samples were collected from the mother (at the beginning of delivery and start of expulsive period) and from neonate (from umbilical cord vein and artery).
Results:
The mothers of girls featured a higher total antioxidant status and lower plasma hydroperoxides than the mother of boys. Regarding the neonates, the girls featured a higher total antioxidant status and lower plasma membrane hydroperoxides in umbilical cord artery together with higher catalase, glutathione peroxidase, and superoxide dismutase activities. Lower levels of interleukin 6, tumor necrosis factor alpha, and prostaglandin E2 were observed in the mothers of girls and higher level of soluble tumor necrosis factor receptor II. In the neonates, lower levels of interleukin 6 and tumor necrosis factor alpha were observed in umbilical artery and higher soluble tumor necrosis factor receptor II in umbilical cord vein and artery of girls.
Conclusion:
An association between gender, oxidative stress, and inflammation signaling exists, leading to a renewed interest in the neonate’s sex as a potential risk factor to several alterations. |
| doi_str_mv | 10.1038/pr.2016.112 |
| format | Article |
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Gender is a crucial determinant of life span, but little is known about gender differences in free radical homeostasis and inflammatory signaling. The aim of the study was to determine gender-related differences concerning oxidative stress and inflammatory signaling of healthy neonates and mothers.
Methods:
Fifty-six mothers with normal gestational course and spontaneous delivery were selected. Blood samples were collected from the mother (at the beginning of delivery and start of expulsive period) and from neonate (from umbilical cord vein and artery).
Results:
The mothers of girls featured a higher total antioxidant status and lower plasma hydroperoxides than the mother of boys. Regarding the neonates, the girls featured a higher total antioxidant status and lower plasma membrane hydroperoxides in umbilical cord artery together with higher catalase, glutathione peroxidase, and superoxide dismutase activities. Lower levels of interleukin 6, tumor necrosis factor alpha, and prostaglandin E2 were observed in the mothers of girls and higher level of soluble tumor necrosis factor receptor II. In the neonates, lower levels of interleukin 6 and tumor necrosis factor alpha were observed in umbilical artery and higher soluble tumor necrosis factor receptor II in umbilical cord vein and artery of girls.
Conclusion:
An association between gender, oxidative stress, and inflammation signaling exists, leading to a renewed interest in the neonate’s sex as a potential risk factor to several alterations.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/pr.2016.112</identifier><identifier>PMID: 27331351</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/80/86/2366 ; 692/499 ; 692/700/1720/3186 ; Adult ; Antioxidants - metabolism ; basic-science-investigation ; Catalase - blood ; Dinoprostone - blood ; Female ; Free radicals ; Gender ; Glutathione Peroxidase - blood ; Humans ; Hydrogen Peroxide - blood ; Infant, Newborn ; Inflammation - metabolism ; Interleukin-6 - blood ; Male ; Medicine & Public Health ; Mothers ; Oxidative Stress ; Pediatric Surgery ; Pediatrics ; Pregnancy ; Sex Factors ; Signal Transduction ; Superoxide Dismutase - blood ; Tumor Necrosis Factor-alpha - blood ; Umbilical Arteries - metabolism ; Umbilical Cord - metabolism</subject><ispartof>Pediatric research, 2016-10, Vol.80 (4), p.595-601</ispartof><rights>International Pediatric Research Foundation, Inc. 2016</rights><rights>Copyright Nature Publishing Group Oct 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-cfa472eaeb16e2f698d26783519759fc55e934fe0c5d1282c9e0ae9786e8fe3c3</citedby><cites>FETCH-LOGICAL-c354t-cfa472eaeb16e2f698d26783519759fc55e934fe0c5d1282c9e0ae9786e8fe3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27331351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diaz-Castro, Javier</creatorcontrib><creatorcontrib>Pulido-Moran, Mario</creatorcontrib><creatorcontrib>Moreno-Fernandez, Jorge</creatorcontrib><creatorcontrib>Kajarabille, Naroa</creatorcontrib><creatorcontrib>de Paco, Catalina</creatorcontrib><creatorcontrib>Garrido-Sanchez, Maria</creatorcontrib><creatorcontrib>Prados, Sonia</creatorcontrib><creatorcontrib>Ochoa, Julio J.</creatorcontrib><title>Gender specific differences in oxidative stress and inflammatory signaling in healthy term neonates and their mothers</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background:
Gender is a crucial determinant of life span, but little is known about gender differences in free radical homeostasis and inflammatory signaling. The aim of the study was to determine gender-related differences concerning oxidative stress and inflammatory signaling of healthy neonates and mothers.
Methods:
Fifty-six mothers with normal gestational course and spontaneous delivery were selected. Blood samples were collected from the mother (at the beginning of delivery and start of expulsive period) and from neonate (from umbilical cord vein and artery).
Results:
The mothers of girls featured a higher total antioxidant status and lower plasma hydroperoxides than the mother of boys. Regarding the neonates, the girls featured a higher total antioxidant status and lower plasma membrane hydroperoxides in umbilical cord artery together with higher catalase, glutathione peroxidase, and superoxide dismutase activities. Lower levels of interleukin 6, tumor necrosis factor alpha, and prostaglandin E2 were observed in the mothers of girls and higher level of soluble tumor necrosis factor receptor II. In the neonates, lower levels of interleukin 6 and tumor necrosis factor alpha were observed in umbilical artery and higher soluble tumor necrosis factor receptor II in umbilical cord vein and artery of girls.
Conclusion:
An association between gender, oxidative stress, and inflammation signaling exists, leading to a renewed interest in the neonate’s sex as a potential risk factor to several alterations.</description><subject>631/80/86/2366</subject><subject>692/499</subject><subject>692/700/1720/3186</subject><subject>Adult</subject><subject>Antioxidants - metabolism</subject><subject>basic-science-investigation</subject><subject>Catalase - blood</subject><subject>Dinoprostone - blood</subject><subject>Female</subject><subject>Free radicals</subject><subject>Gender</subject><subject>Glutathione Peroxidase - blood</subject><subject>Humans</subject><subject>Hydrogen Peroxide - blood</subject><subject>Infant, Newborn</subject><subject>Inflammation - metabolism</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Medicine & Public Health</subject><subject>Mothers</subject><subject>Oxidative Stress</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Sex Factors</subject><subject>Signal Transduction</subject><subject>Superoxide Dismutase - blood</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Umbilical Arteries - metabolism</subject><subject>Umbilical Cord - metabolism</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkUtr3DAUhUVpaCaPVfdF0E0h8VRPW1qGkBcEsknXRiNfzSjY8lSSQ-bfV2amoZSsLlf6dO7RPQh9pWRJCVc_t3HJCK2XlLJPaEElJxURovmMFoRwWnGt1TE6SemFECqkEl_QMWs4p1zSBZruIHQQcdqC9c5b3HnnIEKwkLAPeHzzncn-FXDKEVLCJnTl3PVmGEwe4w4nvw6m92E94xswfd7scIY44ABjMBn2b_IGfMTDWGpMZ-jImT7B-aGeol-3N8_X99Xj093D9dVjZbkUubLOiIaBgRWtgblaq47VjSrGdSO1s1KC5sIBsbKjTDGrgRjQjapBOeCWn6Ife91tHH9PkHI7-GSh703xNqWWKkakbjRXBf3-H_oyTrH8bKYEY7QmYqYu9pSNY0oRXLuNfjBx11LSzmmUvp3TaEsahf520JxWA3Tv7N_1F-ByD6RyFdYQ_xn6gd4f_JiVGA</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Diaz-Castro, Javier</creator><creator>Pulido-Moran, Mario</creator><creator>Moreno-Fernandez, Jorge</creator><creator>Kajarabille, Naroa</creator><creator>de Paco, Catalina</creator><creator>Garrido-Sanchez, Maria</creator><creator>Prados, Sonia</creator><creator>Ochoa, Julio J.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Gender specific differences in oxidative stress and inflammatory signaling in healthy term neonates and their mothers</title><author>Diaz-Castro, Javier ; Pulido-Moran, Mario ; Moreno-Fernandez, Jorge ; Kajarabille, Naroa ; de Paco, Catalina ; Garrido-Sanchez, Maria ; Prados, Sonia ; Ochoa, Julio J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-cfa472eaeb16e2f698d26783519759fc55e934fe0c5d1282c9e0ae9786e8fe3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/80/86/2366</topic><topic>692/499</topic><topic>692/700/1720/3186</topic><topic>Adult</topic><topic>Antioxidants - metabolism</topic><topic>basic-science-investigation</topic><topic>Catalase - blood</topic><topic>Dinoprostone - blood</topic><topic>Female</topic><topic>Free radicals</topic><topic>Gender</topic><topic>Glutathione Peroxidase - blood</topic><topic>Humans</topic><topic>Hydrogen Peroxide - blood</topic><topic>Infant, Newborn</topic><topic>Inflammation - metabolism</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Medicine & Public Health</topic><topic>Mothers</topic><topic>Oxidative Stress</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Sex Factors</topic><topic>Signal Transduction</topic><topic>Superoxide Dismutase - blood</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Umbilical Arteries - metabolism</topic><topic>Umbilical Cord - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diaz-Castro, Javier</creatorcontrib><creatorcontrib>Pulido-Moran, Mario</creatorcontrib><creatorcontrib>Moreno-Fernandez, Jorge</creatorcontrib><creatorcontrib>Kajarabille, Naroa</creatorcontrib><creatorcontrib>de Paco, Catalina</creatorcontrib><creatorcontrib>Garrido-Sanchez, Maria</creatorcontrib><creatorcontrib>Prados, Sonia</creatorcontrib><creatorcontrib>Ochoa, Julio J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diaz-Castro, Javier</au><au>Pulido-Moran, Mario</au><au>Moreno-Fernandez, Jorge</au><au>Kajarabille, Naroa</au><au>de Paco, Catalina</au><au>Garrido-Sanchez, Maria</au><au>Prados, Sonia</au><au>Ochoa, Julio J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender specific differences in oxidative stress and inflammatory signaling in healthy term neonates and their mothers</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>80</volume><issue>4</issue><spage>595</spage><epage>601</epage><pages>595-601</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background:
Gender is a crucial determinant of life span, but little is known about gender differences in free radical homeostasis and inflammatory signaling. The aim of the study was to determine gender-related differences concerning oxidative stress and inflammatory signaling of healthy neonates and mothers.
Methods:
Fifty-six mothers with normal gestational course and spontaneous delivery were selected. Blood samples were collected from the mother (at the beginning of delivery and start of expulsive period) and from neonate (from umbilical cord vein and artery).
Results:
The mothers of girls featured a higher total antioxidant status and lower plasma hydroperoxides than the mother of boys. Regarding the neonates, the girls featured a higher total antioxidant status and lower plasma membrane hydroperoxides in umbilical cord artery together with higher catalase, glutathione peroxidase, and superoxide dismutase activities. Lower levels of interleukin 6, tumor necrosis factor alpha, and prostaglandin E2 were observed in the mothers of girls and higher level of soluble tumor necrosis factor receptor II. In the neonates, lower levels of interleukin 6 and tumor necrosis factor alpha were observed in umbilical artery and higher soluble tumor necrosis factor receptor II in umbilical cord vein and artery of girls.
Conclusion:
An association between gender, oxidative stress, and inflammation signaling exists, leading to a renewed interest in the neonate’s sex as a potential risk factor to several alterations.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>27331351</pmid><doi>10.1038/pr.2016.112</doi><tpages>7</tpages></addata></record> |
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| subjects | 631/80/86/2366 692/499 692/700/1720/3186 Adult Antioxidants - metabolism basic-science-investigation Catalase - blood Dinoprostone - blood Female Free radicals Gender Glutathione Peroxidase - blood Humans Hydrogen Peroxide - blood Infant, Newborn Inflammation - metabolism Interleukin-6 - blood Male Medicine & Public Health Mothers Oxidative Stress Pediatric Surgery Pediatrics Pregnancy Sex Factors Signal Transduction Superoxide Dismutase - blood Tumor Necrosis Factor-alpha - blood Umbilical Arteries - metabolism Umbilical Cord - metabolism |
| title | Gender specific differences in oxidative stress and inflammatory signaling in healthy term neonates and their mothers |
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