Protection of neonatal rat cardiac myocytes against radiation-induced damage with agonists of growth hormone-releasing hormone

[Display omitted] Despite the great clinical significance of radiation-induced cardiac damage, experimental investigation of its mechanisms is an unmet need in medicine. Beneficial effects of growth hormone-releasing hormone (GHRH) agonists in regeneration of the heart have been demonstrated. The ai...

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Veröffentlicht in:	Pharmacological research 2016-09, Vol.111, p.859-866
Hauptverfasser:	Kiscsatári, Laura, Varga, Zoltán, Schally, Andrew V., Gáspár, Renáta, Nagy, Csilla Terézia, Giricz, Zoltán, Ferdinandy, Péter, Fábián, Gabriella, Kahán, Zsuzsanna, Görbe, Anikó
Format:	Artikel
Sprache:	eng
Schlagworte:	Alprostadil - analogs & derivatives Alprostadil - pharmacology Animals Animals, Newborn Cardiac myocytes Cardioprotection Cardiotoxicity Cell Proliferation - drug effects Cell Proliferation - radiation effects Cell Survival - drug effects Cell Survival - radiation effects Cells, Cultured Cytoprotection Dose-Response Relationship, Drug GHRH agonists GHRH/SV1 receptors Growth Hormone-Releasing Hormone - agonists Growth Hormone-Releasing Hormone - analogs & derivatives Growth Hormone-Releasing Hormone - metabolism Growth Hormone-Releasing Hormone - pharmacology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Myocytes, Cardiac - radiation effects Peptide Fragments - pharmacology Radiation damage Radiation-Protective Agents - pharmacology Rats, Wistar Reactive Oxygen Species - metabolism Receptors, Neuropeptide - agonists Receptors, Neuropeptide - metabolism Receptors, Pituitary Hormone-Regulating Hormone - agonists Receptors, Pituitary Hormone-Regulating Hormone - metabolism Signal Transduction - drug effects Signal Transduction - radiation effects
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