Hydroxypyridyl Imines: Enhancing Chromatographic Separation and Stereochemical Analysis of Chiral Amines via Circular Dichroism

Imine-bond formation between chiral amines and commercially available 3-hydroxypyridine-2-carboxaldehyde (HCA) was exploited for rapid determination of stereochemical composition. Chiral supercritical fluid chromatography (SFC) screening of the derivatized imine compounds led to the elucidation of m...

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Veröffentlicht in:	Journal of organic chemistry 2016-09, Vol.81 (18), p.8199-8205
Hauptverfasser:	Joyce, Leo A, Regalado, Erik L, Welch, Christopher J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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