Caveats of Untargeted Metabolomics for Biomarker Discovery
High-abundant metabolites can suppress the ionization of low-abundant metabolites by picking up most of the available charges at the cone of the spray tip (6). [...]the signal intensity is not solely dependent on the plasma concentration of the metabolite. [...]many issues remain to be addressed bef...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2016-09, Vol.68 (12), p.1294-1296 |
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| container_end_page | 1296 |
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| container_issue | 12 |
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| container_title | Journal of the American College of Cardiology |
| container_volume | 68 |
| creator | Baig, Ferheen, MSc Pechlaner, Raimund, MD, PhD Mayr, Manuel, MD, PhD |
| description | High-abundant metabolites can suppress the ionization of low-abundant metabolites by picking up most of the available charges at the cone of the spray tip (6). [...]the signal intensity is not solely dependent on the plasma concentration of the metabolite. [...]many issues remain to be addressed before claims can be made regarding the clinical utility of the presented findings (1), in particular the pre-analytical variation and confounding by medication, the reproducibility of the measurements, and most importantly, whether the additional information ultimately helps the clinician to manage patients and guide treatment decision by outperforming existing biomarkers (10). |
| doi_str_mv | 10.1016/j.jacc.2016.05.098 |
| format | Article |
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| subjects | Accuracy Angina pectoris Biomarkers Biomedical Research Cardiology Cardiovascular Cardiovascular disease Chromatography, High Pressure Liquid Chromatography, Liquid Confidence intervals Coronary vessels Discriminant analysis Heart attacks Identification Internal Medicine liquid chromatography Mass Spectrometry Metabolism Metabolites Metabolomics myocardial infarction NMR Nuclear magnetic resonance Plasma Retention Studies |
| title | Caveats of Untargeted Metabolomics for Biomarker Discovery |
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