Copper transporters and chaperones CTR1, CTR2, ATOX1, and CCS as determinants of cisplatin sensitivity

The development of resistance to cisplatin (cDDP) is commonly accompanied by reduced drug uptake or increased efflux. Previous studies in yeast and murine embryonic fibroblasts have reported that the copper (Cu) transporters and chaperones participate in the uptake, efflux, and intracellular distrib...

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Veröffentlicht in:	Metallomics 2016-09, Vol.8 (9), p.951-962
Hauptverfasser:	Bompiani, Kristin M, Tsai, Cheng-Yu, Achatz, Felix P, Liebig, Janika K, Howell, Stephen B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Cation Transport Proteins - metabolism Cell Proliferation - drug effects Cells, Cultured Cisplatin - pharmacology Copper - metabolism Drug Resistance, Neoplasm Female Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Humans Mice Mice, Inbred BALB C Mice, Nude Molecular Chaperones - metabolism Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Xenograft Model Antitumor Assays
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