The application of next-generation sequencing-based molecular diagnostics in endometrial stromal sarcoma

Aims Endometrial stromal sarcomas (ESSs) are divided into low‐grade and high‐grade subtypes, with the latter showing more aggressive clinical behaviour. Although histology and immunophenotype can aid in the diagnosis of these tumours, genetic studies can provide additional diagnostic insights, as lo...

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Veröffentlicht in:	Histopathology 2016-10, Vol.69 (4), p.551-559
Hauptverfasser:	Li, Xiaodong, Anand, Mona, Haimes, Josh D, Manoj, Namitha, Berlin, Aaron M, Kudlow, Brian A, Nucci, Marisa R, Ng, Tony L, Stewart, Colin J R, Lee, Cheng-Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Endometrial Neoplasms - diagnosis Endometrial Neoplasms - genetics endometrial stromal sarcoma Endometrial Stromal Tumors - diagnosis Endometrial Stromal Tumors - genetics FAM22A FAM22B Female Genes genetic fusion High-Throughput Nucleotide Sequencing - methods Humans JAZF1 Middle Aged NUTM2A NUTM2B Oncogene Proteins, Fusion - analysis Pathology, Molecular PHF1 Polymerase chain reaction Sarcoma, Endometrial Stromal - diagnosis Sarcoma, Endometrial Stromal - genetics Sensitivity and Specificity SUZ12 Young Adult YWHAE
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