Differential effects of two NMDA receptor antagonists on cognitive–behavioral performance in young nonhuman primates II

The present experiment examined the effects of chronic exposure to remacemide (an NMDA antagonist that also blocks fast sodium channels) or MK-801 (which blocks NMDA receptors more selectively) on the acquisition of color and position discrimination and short-term memory behavior in juvenile rhesus...

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Veröffentlicht in:	Neurotoxicology and teratology 2001-07, Vol.23 (4), p.333-347
Hauptverfasser:	Popke, E.J, Allen, R.R, Pearson, E.C, Hammond, T.G, Paule, M.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacology Animals Biological and medical sciences Cognition - drug effects Color and position discrimination Color Perception - drug effects Color Perception - physiology Conditioning, Operant - drug effects Discrimination (Psychology) - drug effects dizocilpine maleate Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Fast sodium channels Female Macaca mulatta Medical sciences Memory, Short-Term - drug effects Memory, Short-Term - physiology MK-801 N-methyl- d-aspartate (NMDA) Neuroprotective Agents - pharmacology Operant behavior Pharmacology. Drug treatments Pregnancy Prenatal Exposure Delayed Effects Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Remacemide Restraint, Physical Reward Rhesus monkeys Short-term memory Substance Withdrawal Syndrome Toxicity: nervous system and muscle
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