Microfluidics-Produced Collagen Fibers Show Extraordinary Mechanical Properties

Collagens are widely used as biomaterials in drug-delivery and tissue engineering applications due to their biodegradability, biocompatibility and hypoallergenicity. Besides gelatin-based materials, collagen microfibers are in the focus of biomedical research. Commonly, man-made fibers are produced...

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Veröffentlicht in:	Nano letters 2016-09, Vol.16 (9), p.5917-5922
Hauptverfasser:	Haynl, Christian, Hofmann, Eddie, Pawar, Kiran, Förster, Stephan, Scheibel, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials - chemistry Cell Line, Tumor Collagen Type I - chemistry Mice Microfluidics Rats Tensile Strength Tissue Engineering
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creator	Haynl, Christian Hofmann, Eddie Pawar, Kiran Förster, Stephan Scheibel, Thomas
description	Collagens are widely used as biomaterials in drug-delivery and tissue engineering applications due to their biodegradability, biocompatibility and hypoallergenicity. Besides gelatin-based materials, collagen microfibers are in the focus of biomedical research. Commonly, man-made fibers are produced by wet-spinning yielding fiber diameters higher than 8 μm. Here, assembly and continuous production of single collagen type I microfibers were established using a microfluidic chip. Microfluidics-produced microfibers exhibited tensile strength and Young’s modulus exceeding that of fibers produced in classical wet-spinning devices and even that of natural tendon and they showed lower diameters. Their structural orientation was examined by polarized Fourier transform infrared spectroscopy (FTIR) showing fibril alignment within the microfiber. Cell culture tests using the neuronal cell line NG108-15 showed cell alignment and axon growth along the microfiber axes inaugurating potential applications in, for example, peripheral nerve repair.
doi_str_mv	10.1021/acs.nanolett.6b02828
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subjects	Animals Biocompatible Materials - chemistry Cell Line, Tumor Collagen Type I - chemistry Mice Microfluidics Rats Tensile Strength Tissue Engineering
title	Microfluidics-Produced Collagen Fibers Show Extraordinary Mechanical Properties
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