C. elegans Slit Acts in Midline, Dorsal-Ventral, and Anterior-Posterior Guidance via the SAX-3/Robo Receptor
Robo receptors interact with ligands of the Slit family. The nematode C. elegans has one Robo receptor (SAX-3) and one Slit protein (SLT-1), which direct ventral axon guidance and guidance at the midline. In larvae, slt-1 expression in dorsal muscles repels axons to promote ventral guidance. SLT-1 a...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2001-10, Vol.32 (1), p.25-38 |
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| container_title | Neuron (Cambridge, Mass.) |
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| creator | Hao, Joe C Yu, Timothy W Fujisawa, Kazuko Culotti, Joseph G Gengyo-Ando, Keiko Mitani, Shohei Moulder, Gary Barstead, Robert Tessier-Lavigne, Marc Bargmann, Cornelia I |
| description | Robo receptors interact with ligands of the Slit family. The nematode
C. elegans has one Robo receptor (SAX-3) and one Slit protein (SLT-1), which direct ventral axon guidance and guidance at the midline. In larvae,
slt-1 expression in dorsal muscles repels axons to promote ventral guidance. SLT-1 acts through the SAX-3 receptor, in parallel with the ventral attractant UNC-6 (Netrin). Removing both UNC-6 and SLT-1 eliminates all ventral guidance information for some axons, revealing an underlying longitudinal guidance pathway. In the embryo,
slt-1 is expressed at high levels in anterior epidermis. Embryonic expression of SLT-1 provides anterior-posterior guidance information to migrating CAN neurons. Surprisingly,
slt-1 mutants do not exhibit the nerve ring and epithelial defects of
sax-3 mutants, suggesting that SAX-3 has both Slit-dependent and Slit-independent functions in development. |
| doi_str_mv | 10.1016/S0896-6273(01)00448-2 |
| format | Article |
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C. elegans has one Robo receptor (SAX-3) and one Slit protein (SLT-1), which direct ventral axon guidance and guidance at the midline. In larvae,
slt-1 expression in dorsal muscles repels axons to promote ventral guidance. SLT-1 acts through the SAX-3 receptor, in parallel with the ventral attractant UNC-6 (Netrin). Removing both UNC-6 and SLT-1 eliminates all ventral guidance information for some axons, revealing an underlying longitudinal guidance pathway. In the embryo,
slt-1 is expressed at high levels in anterior epidermis. Embryonic expression of SLT-1 provides anterior-posterior guidance information to migrating CAN neurons. Surprisingly,
slt-1 mutants do not exhibit the nerve ring and epithelial defects of
sax-3 mutants, suggesting that SAX-3 has both Slit-dependent and Slit-independent functions in development.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/S0896-6273(01)00448-2</identifier><identifier>PMID: 11604136</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Axons - physiology ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins ; Cell Movement ; Gene Expression Regulation, Developmental ; Green Fluorescent Proteins ; Helminth Proteins - genetics ; Helminth Proteins - metabolism ; Indicators and Reagents - metabolism ; Luminescent Proteins - genetics ; Muscles - innervation ; Muscles - physiology ; Mutagenesis - physiology ; Nerve Tissue Proteins - chemistry ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; netrin ; Netrins ; Neurons - physiology ; Neurons - ultrastructure ; Protein Structure, Tertiary ; Receptors, Immunologic - genetics ; Receptors, Immunologic - metabolism ; Robo protein ; Roundabout Proteins ; Slit1 protein</subject><ispartof>Neuron (Cambridge, Mass.), 2001-10, Vol.32 (1), p.25-38</ispartof><rights>2001 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-5977f115e8155cd10df2d13ae96af382a4e04a9eae021bc071f3acd76b882dfc3</citedby><cites>FETCH-LOGICAL-c559t-5977f115e8155cd10df2d13ae96af382a4e04a9eae021bc071f3acd76b882dfc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0896627301004482$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11604136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hao, Joe C</creatorcontrib><creatorcontrib>Yu, Timothy W</creatorcontrib><creatorcontrib>Fujisawa, Kazuko</creatorcontrib><creatorcontrib>Culotti, Joseph G</creatorcontrib><creatorcontrib>Gengyo-Ando, Keiko</creatorcontrib><creatorcontrib>Mitani, Shohei</creatorcontrib><creatorcontrib>Moulder, Gary</creatorcontrib><creatorcontrib>Barstead, Robert</creatorcontrib><creatorcontrib>Tessier-Lavigne, Marc</creatorcontrib><creatorcontrib>Bargmann, Cornelia I</creatorcontrib><title>C. elegans Slit Acts in Midline, Dorsal-Ventral, and Anterior-Posterior Guidance via the SAX-3/Robo Receptor</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>Robo receptors interact with ligands of the Slit family. The nematode
C. elegans has one Robo receptor (SAX-3) and one Slit protein (SLT-1), which direct ventral axon guidance and guidance at the midline. In larvae,
slt-1 expression in dorsal muscles repels axons to promote ventral guidance. SLT-1 acts through the SAX-3 receptor, in parallel with the ventral attractant UNC-6 (Netrin). Removing both UNC-6 and SLT-1 eliminates all ventral guidance information for some axons, revealing an underlying longitudinal guidance pathway. In the embryo,
slt-1 is expressed at high levels in anterior epidermis. Embryonic expression of SLT-1 provides anterior-posterior guidance information to migrating CAN neurons. Surprisingly,
slt-1 mutants do not exhibit the nerve ring and epithelial defects of
sax-3 mutants, suggesting that SAX-3 has both Slit-dependent and Slit-independent functions in development.</description><subject>Animals</subject><subject>Axons - physiology</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans Proteins</subject><subject>Cell Movement</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Green Fluorescent Proteins</subject><subject>Helminth Proteins - genetics</subject><subject>Helminth Proteins - metabolism</subject><subject>Indicators and Reagents - metabolism</subject><subject>Luminescent Proteins - genetics</subject><subject>Muscles - innervation</subject><subject>Muscles - physiology</subject><subject>Mutagenesis - physiology</subject><subject>Nerve Tissue Proteins - chemistry</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>netrin</subject><subject>Netrins</subject><subject>Neurons - physiology</subject><subject>Neurons - ultrastructure</subject><subject>Protein Structure, Tertiary</subject><subject>Receptors, Immunologic - genetics</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Robo protein</subject><subject>Roundabout Proteins</subject><subject>Slit1 protein</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhi1ERVLgJxT5hFoJg2e_faqitKWVqEAJoN4srz1LjZx1ajuR-PfdsFE59jRzeN55NQ8hH4BfAofqaskbUbEqq_OPHD5xXhQNyw7IFLioWQFCHJLpP2RC3sf4zDkUpYAjMgGoeAF5NSVufknR4ZPqI106m-hMp0htT39a42yPF_SLD1E59oh9CspdUNUbOusTBusDu_Nx3Oj1xhrVa6Rbq2j6jXQ5-8Xyq4VvPV2gxnXy4YS865SLeLqfx-Th29f7-Xd2c3v9Yz67YbosRWKlqOsOoMQGylIb4KbLDOQKRaW6vMlUgbxQAhXyDFrNa-hypU1dtU2TmU7nx-R8vLsO_s8GY5IrGzU6p3r0myihAdEMJQNYjqAOPsaAnVwHu1LhRQKXO83yVbPcOZQc5KtmmQ25s33Bpl2heUvtvQ7A5xHA4c2txSCjtjjoMTagTtJ4-5-Kv0SDi_A</recordid><startdate>20011011</startdate><enddate>20011011</enddate><creator>Hao, Joe C</creator><creator>Yu, Timothy W</creator><creator>Fujisawa, Kazuko</creator><creator>Culotti, Joseph G</creator><creator>Gengyo-Ando, Keiko</creator><creator>Mitani, Shohei</creator><creator>Moulder, Gary</creator><creator>Barstead, Robert</creator><creator>Tessier-Lavigne, Marc</creator><creator>Bargmann, Cornelia I</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20011011</creationdate><title>C. elegans Slit Acts in Midline, Dorsal-Ventral, and Anterior-Posterior Guidance via the SAX-3/Robo Receptor</title><author>Hao, Joe C ; Yu, Timothy W ; Fujisawa, Kazuko ; Culotti, Joseph G ; Gengyo-Ando, Keiko ; Mitani, Shohei ; Moulder, Gary ; Barstead, Robert ; Tessier-Lavigne, Marc ; Bargmann, Cornelia I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-5977f115e8155cd10df2d13ae96af382a4e04a9eae021bc071f3acd76b882dfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Axons - physiology</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans Proteins</topic><topic>Cell Movement</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Green Fluorescent Proteins</topic><topic>Helminth Proteins - genetics</topic><topic>Helminth Proteins - metabolism</topic><topic>Indicators and Reagents - metabolism</topic><topic>Luminescent Proteins - genetics</topic><topic>Muscles - innervation</topic><topic>Muscles - physiology</topic><topic>Mutagenesis - physiology</topic><topic>Nerve Tissue Proteins - chemistry</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>netrin</topic><topic>Netrins</topic><topic>Neurons - physiology</topic><topic>Neurons - ultrastructure</topic><topic>Protein Structure, Tertiary</topic><topic>Receptors, Immunologic - genetics</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Robo protein</topic><topic>Roundabout Proteins</topic><topic>Slit1 protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hao, Joe C</creatorcontrib><creatorcontrib>Yu, Timothy W</creatorcontrib><creatorcontrib>Fujisawa, Kazuko</creatorcontrib><creatorcontrib>Culotti, Joseph G</creatorcontrib><creatorcontrib>Gengyo-Ando, Keiko</creatorcontrib><creatorcontrib>Mitani, Shohei</creatorcontrib><creatorcontrib>Moulder, Gary</creatorcontrib><creatorcontrib>Barstead, Robert</creatorcontrib><creatorcontrib>Tessier-Lavigne, Marc</creatorcontrib><creatorcontrib>Bargmann, Cornelia I</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hao, Joe C</au><au>Yu, Timothy W</au><au>Fujisawa, Kazuko</au><au>Culotti, Joseph G</au><au>Gengyo-Ando, Keiko</au><au>Mitani, Shohei</au><au>Moulder, Gary</au><au>Barstead, Robert</au><au>Tessier-Lavigne, Marc</au><au>Bargmann, Cornelia I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C. elegans Slit Acts in Midline, Dorsal-Ventral, and Anterior-Posterior Guidance via the SAX-3/Robo Receptor</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2001-10-11</date><risdate>2001</risdate><volume>32</volume><issue>1</issue><spage>25</spage><epage>38</epage><pages>25-38</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>Robo receptors interact with ligands of the Slit family. The nematode
C. elegans has one Robo receptor (SAX-3) and one Slit protein (SLT-1), which direct ventral axon guidance and guidance at the midline. In larvae,
slt-1 expression in dorsal muscles repels axons to promote ventral guidance. SLT-1 acts through the SAX-3 receptor, in parallel with the ventral attractant UNC-6 (Netrin). Removing both UNC-6 and SLT-1 eliminates all ventral guidance information for some axons, revealing an underlying longitudinal guidance pathway. In the embryo,
slt-1 is expressed at high levels in anterior epidermis. Embryonic expression of SLT-1 provides anterior-posterior guidance information to migrating CAN neurons. Surprisingly,
slt-1 mutants do not exhibit the nerve ring and epithelial defects of
sax-3 mutants, suggesting that SAX-3 has both Slit-dependent and Slit-independent functions in development.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11604136</pmid><doi>10.1016/S0896-6273(01)00448-2</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Axons - physiology Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Movement Gene Expression Regulation, Developmental Green Fluorescent Proteins Helminth Proteins - genetics Helminth Proteins - metabolism Indicators and Reagents - metabolism Luminescent Proteins - genetics Muscles - innervation Muscles - physiology Mutagenesis - physiology Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism netrin Netrins Neurons - physiology Neurons - ultrastructure Protein Structure, Tertiary Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Robo protein Roundabout Proteins Slit1 protein |
| title | C. elegans Slit Acts in Midline, Dorsal-Ventral, and Anterior-Posterior Guidance via the SAX-3/Robo Receptor |
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