The ratio between CcdA and CcdB modulates the transcriptional repression of the ccd poison–antidote system

The ccd operon of the F plasmid encodes CcdB, a toxin targeting the essential gyrase of Escherichia coli, and CcdA, the unstable antidote that interacts with CcdB to neutralize its toxicity. Although work from our group and others has established that CcdA and CcdB are required for transcriptional r...

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Veröffentlicht in:	Molecular microbiology 2001-07, Vol.41 (1), p.73-82
Hauptverfasser:	Afif, Hassan, Allali, Noureddine, Couturier, Martine, Van Melderen, Laurence
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Toxins - genetics Bacterial Toxins - metabolism ccd gene CcdA protein CcdB protein DNA, Bacterial - metabolism Electrophoresis, Polyacrylamide Gel Escherichia coli Escherichia coli - genetics Gene Expression Regulation, Bacterial Mutation Operator Regions, Genetic - genetics Operator Regions, Genetic - physiology Operon - genetics Plasmids - genetics Promoter Regions, Genetic - genetics Promoter Regions, Genetic - physiology Transcription, Genetic
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