Toxicity of domoic acid in the marine mussel Mytilus edulis
The neurotoxic, immunotoxic and genotoxic effects of domoic acid (DA) on the blue mussel Mytilus edulis were investigated by biomarkers, acethylcholinesterase (ChE) activity in gills, DNA fragmentation in digestive glands, vitality and phagocytosis activity of haemocytes in haemolymph of mussels. Af...
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| Veröffentlicht in: | Aquatic toxicology 2001-11, Vol.55 (3), p.149-156 |
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| creator | Dizer, H Fischer, B Harabawy, A.S.A Hennion, M.-C Hansen, P.-D |
| description | The neurotoxic, immunotoxic and genotoxic effects of domoic acid (DA) on the blue mussel
Mytilus edulis were investigated by biomarkers, acethylcholinesterase (ChE) activity in gills, DNA fragmentation in digestive glands, vitality and phagocytosis activity of haemocytes in haemolymph of mussels. After intra muscular injection of DA at the concentrations ranging from 1–500 ng/g body weight (bw), no neurotoxic effect was detected within incubation times of 48 h and 7 d. The vitality of haemocytes remained in all mussels at the level of control samples within 48 h, and increased significantly after 7 d (
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| doi_str_mv | 10.1016/S0166-445X(01)00178-3 |
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Mytilus edulis were investigated by biomarkers, acethylcholinesterase (ChE) activity in gills, DNA fragmentation in digestive glands, vitality and phagocytosis activity of haemocytes in haemolymph of mussels. After intra muscular injection of DA at the concentrations ranging from 1–500 ng/g body weight (bw), no neurotoxic effect was detected within incubation times of 48 h and 7 d. The vitality of haemocytes remained in all mussels at the level of control samples within 48 h, and increased significantly after 7 d (
P<0.05). At DA concentrations ranging from 1 to 100 ng/g bw haemocytes suggested a great phagocytosis activity, but no alteration in their number by both incubation times. By increasing DA concentration of 500 ng/g bw, the number of haemocytes doubled in 48 h without any change in phagocytosis activity. Primary DNA lesions in digestive glands of all injected mussels were determined in acute phase of poisoning within 48 h, and rapidly repaired after 7 d of incubation.</description><identifier>ISSN: 0166-445X</identifier><identifier>EISSN: 1879-1514</identifier><identifier>DOI: 10.1016/S0166-445X(01)00178-3</identifier><identifier>PMID: 11595305</identifier><identifier>CODEN: AQTODG</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Algael toxin ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Bivalvia - immunology ; Cholinesterases - drug effects ; DNA Fragmentation - drug effects ; Domoic acid ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on protozoa and invertebrates ; Fundamental and applied biological sciences. Psychology ; Genotoxicity ; Gills - metabolism ; Gram-Negative Bacterial Infections - immunology ; Gram-Negative Bacterial Infections - veterinary ; Hemocytes - drug effects ; Immune System - drug effects ; Immuno toxicity ; immunotoxicity ; Kainic Acid - analogs & derivatives ; Kainic Acid - toxicity ; Mussels ; Mytilus edulis ; Neuromuscular Depolarizing Agents - toxicity ; Neurotoxicity ; Phagocytosis - drug effects ; Saccharomyces - immunology</subject><ispartof>Aquatic toxicology, 2001-11, Vol.55 (3), p.149-156</ispartof><rights>2001 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-3573e2fcbcc2ecb2fc6d2338e3ef949232b46935deaf415f331007e7daebb4f63</citedby><cites>FETCH-LOGICAL-c422t-3573e2fcbcc2ecb2fc6d2338e3ef949232b46935deaf415f331007e7daebb4f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0166-445X(01)00178-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14116519$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11595305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dizer, H</creatorcontrib><creatorcontrib>Fischer, B</creatorcontrib><creatorcontrib>Harabawy, A.S.A</creatorcontrib><creatorcontrib>Hennion, M.-C</creatorcontrib><creatorcontrib>Hansen, P.-D</creatorcontrib><title>Toxicity of domoic acid in the marine mussel Mytilus edulis</title><title>Aquatic toxicology</title><addtitle>Aquat Toxicol</addtitle><description>The neurotoxic, immunotoxic and genotoxic effects of domoic acid (DA) on the blue mussel
Mytilus edulis were investigated by biomarkers, acethylcholinesterase (ChE) activity in gills, DNA fragmentation in digestive glands, vitality and phagocytosis activity of haemocytes in haemolymph of mussels. After intra muscular injection of DA at the concentrations ranging from 1–500 ng/g body weight (bw), no neurotoxic effect was detected within incubation times of 48 h and 7 d. The vitality of haemocytes remained in all mussels at the level of control samples within 48 h, and increased significantly after 7 d (
P<0.05). At DA concentrations ranging from 1 to 100 ng/g bw haemocytes suggested a great phagocytosis activity, but no alteration in their number by both incubation times. By increasing DA concentration of 500 ng/g bw, the number of haemocytes doubled in 48 h without any change in phagocytosis activity. Primary DNA lesions in digestive glands of all injected mussels were determined in acute phase of poisoning within 48 h, and rapidly repaired after 7 d of incubation.</description><subject>Algael toxin</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Bivalvia - immunology</subject><subject>Cholinesterases - drug effects</subject><subject>DNA Fragmentation - drug effects</subject><subject>Domoic acid</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on protozoa and invertebrates</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotoxicity</subject><subject>Gills - metabolism</subject><subject>Gram-Negative Bacterial Infections - immunology</subject><subject>Gram-Negative Bacterial Infections - veterinary</subject><subject>Hemocytes - drug effects</subject><subject>Immune System - drug effects</subject><subject>Immuno toxicity</subject><subject>immunotoxicity</subject><subject>Kainic Acid - analogs & derivatives</subject><subject>Kainic Acid - toxicity</subject><subject>Mussels</subject><subject>Mytilus edulis</subject><subject>Neuromuscular Depolarizing Agents - toxicity</subject><subject>Neurotoxicity</subject><subject>Phagocytosis - drug effects</subject><subject>Saccharomyces - immunology</subject><issn>0166-445X</issn><issn>1879-1514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCaBsQLAIeGI7acQCoYqXVMSCIrGzHHssjPIocYLo3-M-RJd44ZnFuZ7xIeQY6CVQSK9ew5XGnIv3cwoXlEI2jtkOGcI4y2MQwHfJ8A8ZkAPvP2k4Cc_3yQBA5IJRMSTXs-bHadctosZGpqkapyOlnYlcHXUfGFWqdXUovfdYRs-LzpW9j9D0pfOHZM-q0uPRpo7I2_3dbPIYT18enia301jzJOliJjKGidWF1gnqInSpSRgbI0Ob8zxhScHTnAmDynIQljGgNMPMKCwKblM2Imfrd-dt89Wj72TlvMayVDU2vZcwhjzlfAmKNajbxvsWrZy3LvxgIYHKpTW5siaXSiQFubImWcidbAb0RYVmm9poCsDpBlBeq9K2qtbObzkOkArIA3ez5jDo-HbYSq8d1hqNa1F30jTun1V-AXAEiTQ</recordid><startdate>20011112</startdate><enddate>20011112</enddate><creator>Dizer, H</creator><creator>Fischer, B</creator><creator>Harabawy, A.S.A</creator><creator>Hennion, M.-C</creator><creator>Hansen, P.-D</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7TN</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope></search><sort><creationdate>20011112</creationdate><title>Toxicity of domoic acid in the marine mussel Mytilus edulis</title><author>Dizer, H ; Fischer, B ; Harabawy, A.S.A ; Hennion, M.-C ; Hansen, P.-D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-3573e2fcbcc2ecb2fc6d2338e3ef949232b46935deaf415f331007e7daebb4f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Algael toxin</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Bivalvia - immunology</topic><topic>Cholinesterases - drug effects</topic><topic>DNA Fragmentation - drug effects</topic><topic>Domoic acid</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on protozoa and invertebrates</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotoxicity</topic><topic>Gills - metabolism</topic><topic>Gram-Negative Bacterial Infections - immunology</topic><topic>Gram-Negative Bacterial Infections - veterinary</topic><topic>Hemocytes - drug effects</topic><topic>Immune System - drug effects</topic><topic>Immuno toxicity</topic><topic>immunotoxicity</topic><topic>Kainic Acid - analogs & derivatives</topic><topic>Kainic Acid - toxicity</topic><topic>Mussels</topic><topic>Mytilus edulis</topic><topic>Neuromuscular Depolarizing Agents - toxicity</topic><topic>Neurotoxicity</topic><topic>Phagocytosis - drug effects</topic><topic>Saccharomyces - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dizer, H</creatorcontrib><creatorcontrib>Fischer, B</creatorcontrib><creatorcontrib>Harabawy, A.S.A</creatorcontrib><creatorcontrib>Hennion, M.-C</creatorcontrib><creatorcontrib>Hansen, P.-D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Oceanic Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Aquatic toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dizer, H</au><au>Fischer, B</au><au>Harabawy, A.S.A</au><au>Hennion, M.-C</au><au>Hansen, P.-D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicity of domoic acid in the marine mussel Mytilus edulis</atitle><jtitle>Aquatic toxicology</jtitle><addtitle>Aquat Toxicol</addtitle><date>2001-11-12</date><risdate>2001</risdate><volume>55</volume><issue>3</issue><spage>149</spage><epage>156</epage><pages>149-156</pages><issn>0166-445X</issn><eissn>1879-1514</eissn><coden>AQTODG</coden><abstract>The neurotoxic, immunotoxic and genotoxic effects of domoic acid (DA) on the blue mussel
Mytilus edulis were investigated by biomarkers, acethylcholinesterase (ChE) activity in gills, DNA fragmentation in digestive glands, vitality and phagocytosis activity of haemocytes in haemolymph of mussels. After intra muscular injection of DA at the concentrations ranging from 1–500 ng/g body weight (bw), no neurotoxic effect was detected within incubation times of 48 h and 7 d. The vitality of haemocytes remained in all mussels at the level of control samples within 48 h, and increased significantly after 7 d (
P<0.05). At DA concentrations ranging from 1 to 100 ng/g bw haemocytes suggested a great phagocytosis activity, but no alteration in their number by both incubation times. By increasing DA concentration of 500 ng/g bw, the number of haemocytes doubled in 48 h without any change in phagocytosis activity. Primary DNA lesions in digestive glands of all injected mussels were determined in acute phase of poisoning within 48 h, and rapidly repaired after 7 d of incubation.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11595305</pmid><doi>10.1016/S0166-445X(01)00178-3</doi><tpages>8</tpages></addata></record> |
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| subjects | Algael toxin Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Bivalvia - immunology Cholinesterases - drug effects DNA Fragmentation - drug effects Domoic acid Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on protozoa and invertebrates Fundamental and applied biological sciences. Psychology Genotoxicity Gills - metabolism Gram-Negative Bacterial Infections - immunology Gram-Negative Bacterial Infections - veterinary Hemocytes - drug effects Immune System - drug effects Immuno toxicity immunotoxicity Kainic Acid - analogs & derivatives Kainic Acid - toxicity Mussels Mytilus edulis Neuromuscular Depolarizing Agents - toxicity Neurotoxicity Phagocytosis - drug effects Saccharomyces - immunology |
| title | Toxicity of domoic acid in the marine mussel Mytilus edulis |
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