Indinavir-associated asymptomatic nephrolithiasis and renal cortex atrophy in two HIV-1 infected children
Elevated plasma concentrations of indinavir have been associated with urological complications (renal colic, flank pain or haematuria). The high AUC or the high C sub(max) may thus have contributed to the nephrotoxicity in these two children. We therefore advise the routine monitoring of plasma conc...
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| Veröffentlicht in: | AIDS (London) 2001-09, Vol.15 (13), p.1745-1747 |
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| container_issue | 13 |
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| container_title | AIDS (London) |
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| creator | VAN ROSSUM, Annemarie M. C DIELEMAN, Jeanne P FRAAIJ, Pieter L. A CRANSBERG, Karlien HARTWIG, Nico G GYSSENS, Inge C DE GROOT, Ronald |
| description | Elevated plasma concentrations of indinavir have been associated with urological complications (renal colic, flank pain or haematuria). The high AUC or the high C sub(max) may thus have contributed to the nephrotoxicity in these two children. We therefore advise the routine monitoring of plasma concentrations of indinavir in children and adjusting the dosage in order to reach normal adult plasma concentrations. In addition, we propose regularly performing renal ultrasounds in children who are treated with indinavir and who have an abnormal urinalysis. |
| doi_str_mv | 10.1097/00002030-200109070-00025 |
| format | Article |
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In addition, we propose regularly performing renal ultrasounds in children who are treated with indinavir and who have an abnormal urinalysis.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-200109070-00025</identifier><identifier>PMID: 11546957</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>antiviral agents ; Atrophy - chemically induced ; Biological and medical sciences ; Child, Preschool ; Drug toxicity and drugs side effects treatment ; Female ; HIV Infections - drug therapy ; HIV Protease Inhibitors - adverse effects ; Human immunodeficiency virus 1 ; Humans ; indinavir ; Indinavir - adverse effects ; Kidney Calculi - chemically induced ; Kidney Cortex - pathology ; kidney diseases ; Medical sciences ; Pharmacology. 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In addition, we propose regularly performing renal ultrasounds in children who are treated with indinavir and who have an abnormal urinalysis.</description><subject>antiviral agents</subject><subject>Atrophy - chemically induced</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Protease Inhibitors - adverse effects</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>indinavir</subject><subject>Indinavir - adverse effects</subject><subject>Kidney Calculi - chemically induced</subject><subject>Kidney Cortex - pathology</subject><subject>kidney diseases</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: urogenital system</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPxCAQgInRuOvjLxguekOHAqUcjfGxiYkX9dpQSrOYtlRg1f33su6qc5nM5JtHPoQwhUsKSl5BjgIYkAIgN0AC2XTEHppTLhkRQtJ9NIeiVEQxCTN0FONbRgRU1SGaUSp4qYScI7cYWzfqDxeIjtEbp5NtsY7rYUp-0MkZPNppGXzv0tLp6CLWY4uDHXWPjQ_JfmGdgp-Wa-xGnD49fli8EpqLzprNLrN0fZv5E3TQ6T7a010-Ri93t883D-Tx6X5xc_1IDFM0EdNI4KwQDeeKCWM6WVqhWGnLBlihVMOYyFGpxvJKKugEFAVXQjRMtKa17BhdbPdOwb-vbEz14KKxfa9H61exphVVvBJFBqstaIKPMdiunoIbdFjXFOqN5vpXc_2nuf7RnEfPdjdWzWDb_8Gd1wyc7wAdje67oEfj4j_HQeUPgH0DU6WFOw</recordid><startdate>20010907</startdate><enddate>20010907</enddate><creator>VAN ROSSUM, Annemarie M. C</creator><creator>DIELEMAN, Jeanne P</creator><creator>FRAAIJ, Pieter L. 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| fulltext | fulltext |
| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 2001-09, Vol.15 (13), p.1745-1747 |
| issn | 0269-9370 1473-5571 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | antiviral agents Atrophy - chemically induced Biological and medical sciences Child, Preschool Drug toxicity and drugs side effects treatment Female HIV Infections - drug therapy HIV Protease Inhibitors - adverse effects Human immunodeficiency virus 1 Humans indinavir Indinavir - adverse effects Kidney Calculi - chemically induced Kidney Cortex - pathology kidney diseases Medical sciences Pharmacology. Drug treatments Toxicity: urogenital system |
| title | Indinavir-associated asymptomatic nephrolithiasis and renal cortex atrophy in two HIV-1 infected children |
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