CpG-ODN promotes phagocytosis and autophagy through JNK/P38 signal pathway in Staphylococcus aureus-stimulated macrophage

Phagocytic and autophagic responses are critical for effective host defense against bacterial infection. Bacterial DNA which contains unmethylated Cytosine-phosphate-Guanine (CpG) motifs can trigger a variety of defense mechanisms via Toll-like receptor 9 (TLR9). Here, we aimed to investigate the un...

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Veröffentlicht in:	Life sciences (1973) 2016-09, Vol.161, p.51-59
Hauptverfasser:	Wu, Hui-Mei, Wang, Jiong, Zhang, Bing, Fang, Lei, Xu, Ke, Liu, Rong-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Autophagy - drug effects Bacterial defense Cell Line CpG Macrophage Macrophages - drug effects Macrophages - enzymology Macrophages - immunology Macrophages - microbiology MAP Kinase Kinase 4 - metabolism Mice Oligodeoxyribonucleotides - pharmacology p38 Mitogen-Activated Protein Kinases - metabolism Phagocytosis Phagocytosis - drug effects Signal Transduction Staphylococcus aureus - physiology Toll-like receptor 9
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