Well-Defined Polymer-Paclitaxel Prodrugs by a Grafting-from-Drug Approach

We report on the design of a polymeric prodrug of the anticancer agent paclitaxel (PTX) by a grafting‐from‐drug approach. A chain transfer agent for reversible addition fragmentation chain transfer (RAFT) polymerization was efficiently and regioselectively linked to the C2′ position of paclitaxel, w...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-09, Vol.55 (39), p.11791-11796
Hauptverfasser:	Louage, Benoit, Nuhn, Lutz, Risseeuw, Martijn D. P., Vanparijs, Nane, De Coen, Ruben, Karalic, Izet, Van Calenbergh, Serge, De Geest, Bruno G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Addition polymerization Anticancer properties Antitumor agents Biocompatibility Biological activity cancer Cell Line, Tumor Cell Survival - drug effects Chain transfer Conjugates Cytotoxicity Drug development Endosomes Fluorescence Grafting Humans Hydrophobic and Hydrophilic Interactions nanotechnology Neoplasms - drug therapy Paclitaxel Paclitaxel - analogs & derivatives Paclitaxel - chemical synthesis Paclitaxel - pharmacology Polymerization Polymers Polymers - chemical synthesis Polymers - chemistry Polymers - pharmacology Prodrugs Prodrugs - chemical synthesis Prodrugs - chemistry Prodrugs - pharmacology RAFT polymerization Reagents Solubility Toxicity
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