Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics

Efficacy of chemotherapy in the treatment of distinct malignancies is often hampered by drug resistance arising in the tumor. Understanding the molecular basis of drug resistance and translating this knowledge into personalized treatment decisions can enhance therapeutic efficacy and even curative o...

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Veröffentlicht in:	Drug resistance updates 2016-09, Vol.28, p.65-81
Hauptverfasser:	Wijdeven, Ruud H., Pang, Baoxu, Assaraf, Yehuda G., Neefjes, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer drugs Antineoplastic Agents - therapeutic use Apoptosis - drug effects Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Chemotherapeutics Cisplatin Cisplatin - therapeutic use Doxorubicin (adriamycin) Doxorubicin - therapeutic use Drug resistance Drug Resistance, Multiple - drug effects Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic Humans Molecular Targeted Therapy Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Precision Medicine Signal Transduction
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