Behavioral effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus
Ivermectin is a potent antiparasitic drug against nematode and arthropod parasites. In this study, we examined the lethal and sublethal effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus. The median lethal concentration (LC50) at 72 h after ivermectin exposure was 560 nM. Subl...
Gespeichert in:
| Veröffentlicht in: | Environmental toxicology and chemistry 2001-07, Vol.20 (7), p.1584-1590 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1590 |
|---|---|
| container_issue | 7 |
| container_start_page | 1584 |
| container_title | Environmental toxicology and chemistry |
| container_volume | 20 |
| creator | Ding, Jing Drewes, Charles D. Hsu, Walter H. |
| description | Ivermectin is a potent antiparasitic drug against nematode and arthropod parasites. In this study, we examined the lethal and sublethal effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus. The median lethal concentration (LC50) at 72 h after ivermectin exposure was 560 nM. Sublethal endpoints focused on several stimulus‐evoked locomotor behaviors: escape reflexes controlled by giant interneuron pathways, swimming and reversal, and crawling. Swimming, reversal, and crawling are controlled by nongiant interneuron pathways. Ivermectin inhibited swimming, reversal, crawling frequency, and crawling speed in a time‐ and concentration‐dependent manner with a mean inhibitory concentration (IC50) at 3 h of 1.1, 16, 91, and 51nM, respectively. Ivermectin at 0.3 nM also significantly decreased the frequency of helical swimming waves. Picrotoxin, a Cl− channel blocker, antagonized the ivermectin‐induced decrease in swimming frequency, crawling frequency, and crawling speed. There were no adverse effects on escape reflex 3 h after exposure to 300 nM ivermectin. Electrophysiological recordings showed that ivermectin had no effects on the conduction velocity of giant fiber systems. The results indicated that locomotor behaviors controlled by nongiant locomotor pathways were more sensitive to ivermectin than pathways controlled by giant interneurons and that Cl− channels may be involved in mediating ivermectin's inhibitory effects. |
| doi_str_mv | 10.1002/etc.5620200724 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_18193866</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14581611</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5364-c25f04a36f534c208ae583285d0b0057b5683faa48056479e686546693b469a33</originalsourceid><addsrcrecordid>eNqFkM1PFEEQxTtGIwt69UjmYDwxa3_W9ByFKJqsEiLgsVPTVLMNMzvYPbPIf--Q3QieSCqpVPJ7r6oeY-8EnwvO5Uca_NyA5JLzSuoXbCaMkaUFYV-yGa8ULysJdoft5nzNuYC6rl-zHSG00orLGTs7pCWuY5-wLSgE8kMu-lDENaVuGuKqmAqLkCgv73CgVPRtvOr9Emmgg2Ixdk2KfmzHXKwxRbrCYcxv2KuAbaa3277Hzr98Pjv6Wi5Ojr8dfVqU3ijQpZcmcI0KglHaS26RjFXSmkvecG6qxoBVAVFbbkBXNYEFowFq1WioUak99mHje5v63yPlwXUxe2pbXFE_ZiesqJUFeB7UxgoQYgLnG9CnPudEwd2m2GG6d4K7h8DdFLh7DHwS7G-dx6ajy0d8m_AEvN8CmD22IeHKx_zE1oKSD6_UG-wutnT_zFY3kf_dUG60MQ_0558W042DSlXG_fpx7A7F4jucygv3U_0FmcymyA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14581611</pqid></control><display><type>article</type><title>Behavioral effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ding, Jing ; Drewes, Charles D. ; Hsu, Walter H.</creator><creatorcontrib>Ding, Jing ; Drewes, Charles D. ; Hsu, Walter H.</creatorcontrib><description>Ivermectin is a potent antiparasitic drug against nematode and arthropod parasites. In this study, we examined the lethal and sublethal effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus. The median lethal concentration (LC50) at 72 h after ivermectin exposure was 560 nM. Sublethal endpoints focused on several stimulus‐evoked locomotor behaviors: escape reflexes controlled by giant interneuron pathways, swimming and reversal, and crawling. Swimming, reversal, and crawling are controlled by nongiant interneuron pathways. Ivermectin inhibited swimming, reversal, crawling frequency, and crawling speed in a time‐ and concentration‐dependent manner with a mean inhibitory concentration (IC50) at 3 h of 1.1, 16, 91, and 51nM, respectively. Ivermectin at 0.3 nM also significantly decreased the frequency of helical swimming waves. Picrotoxin, a Cl− channel blocker, antagonized the ivermectin‐induced decrease in swimming frequency, crawling frequency, and crawling speed. There were no adverse effects on escape reflex 3 h after exposure to 300 nM ivermectin. Electrophysiological recordings showed that ivermectin had no effects on the conduction velocity of giant fiber systems. The results indicated that locomotor behaviors controlled by nongiant locomotor pathways were more sensitive to ivermectin than pathways controlled by giant interneurons and that Cl− channels may be involved in mediating ivermectin's inhibitory effects.</description><identifier>ISSN: 0730-7268</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1002/etc.5620200724</identifier><identifier>PMID: 11434302</identifier><identifier>CODEN: ETOCDK</identifier><language>eng</language><publisher>Hoboken: Wiley Periodicals, Inc</publisher><subject>Animal, plant and microbial ecology ; Animals ; Anthelmintics - adverse effects ; Applied ecology ; Behavior ; Behavior, Animal ; Biological and medical sciences ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on protozoa and invertebrates ; Fundamental and applied biological sciences. Psychology ; Interneurons - drug effects ; Interneurons - physiology ; Invertebrate ; Ivermectin ; Ivermectin - adverse effects ; Lethal Dose 50 ; Locomotion ; Locomotion - drug effects ; Lumbriculus variegatus ; Oligochaeta ; picrotoxin ; Sublethal</subject><ispartof>Environmental toxicology and chemistry, 2001-07, Vol.20 (7), p.1584-1590</ispartof><rights>Copyright © 2001 SETAC</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5364-c25f04a36f534c208ae583285d0b0057b5683faa48056479e686546693b469a33</citedby><cites>FETCH-LOGICAL-c5364-c25f04a36f534c208ae583285d0b0057b5683faa48056479e686546693b469a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fetc.5620200724$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fetc.5620200724$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1086323$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11434302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, Jing</creatorcontrib><creatorcontrib>Drewes, Charles D.</creatorcontrib><creatorcontrib>Hsu, Walter H.</creatorcontrib><title>Behavioral effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus</title><title>Environmental toxicology and chemistry</title><addtitle>Environmental Toxicology and Chemistry</addtitle><description>Ivermectin is a potent antiparasitic drug against nematode and arthropod parasites. In this study, we examined the lethal and sublethal effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus. The median lethal concentration (LC50) at 72 h after ivermectin exposure was 560 nM. Sublethal endpoints focused on several stimulus‐evoked locomotor behaviors: escape reflexes controlled by giant interneuron pathways, swimming and reversal, and crawling. Swimming, reversal, and crawling are controlled by nongiant interneuron pathways. Ivermectin inhibited swimming, reversal, crawling frequency, and crawling speed in a time‐ and concentration‐dependent manner with a mean inhibitory concentration (IC50) at 3 h of 1.1, 16, 91, and 51nM, respectively. Ivermectin at 0.3 nM also significantly decreased the frequency of helical swimming waves. Picrotoxin, a Cl− channel blocker, antagonized the ivermectin‐induced decrease in swimming frequency, crawling frequency, and crawling speed. There were no adverse effects on escape reflex 3 h after exposure to 300 nM ivermectin. Electrophysiological recordings showed that ivermectin had no effects on the conduction velocity of giant fiber systems. The results indicated that locomotor behaviors controlled by nongiant locomotor pathways were more sensitive to ivermectin than pathways controlled by giant interneurons and that Cl− channels may be involved in mediating ivermectin's inhibitory effects.</description><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Anthelmintics - adverse effects</subject><subject>Applied ecology</subject><subject>Behavior</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on protozoa and invertebrates</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Interneurons - drug effects</subject><subject>Interneurons - physiology</subject><subject>Invertebrate</subject><subject>Ivermectin</subject><subject>Ivermectin - adverse effects</subject><subject>Lethal Dose 50</subject><subject>Locomotion</subject><subject>Locomotion - drug effects</subject><subject>Lumbriculus variegatus</subject><subject>Oligochaeta</subject><subject>picrotoxin</subject><subject>Sublethal</subject><issn>0730-7268</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1PFEEQxTtGIwt69UjmYDwxa3_W9ByFKJqsEiLgsVPTVLMNMzvYPbPIf--Q3QieSCqpVPJ7r6oeY-8EnwvO5Uca_NyA5JLzSuoXbCaMkaUFYV-yGa8ULysJdoft5nzNuYC6rl-zHSG00orLGTs7pCWuY5-wLSgE8kMu-lDENaVuGuKqmAqLkCgv73CgVPRtvOr9Emmgg2Ixdk2KfmzHXKwxRbrCYcxv2KuAbaa3277Hzr98Pjv6Wi5Ojr8dfVqU3ijQpZcmcI0KglHaS26RjFXSmkvecG6qxoBVAVFbbkBXNYEFowFq1WioUak99mHje5v63yPlwXUxe2pbXFE_ZiesqJUFeB7UxgoQYgLnG9CnPudEwd2m2GG6d4K7h8DdFLh7DHwS7G-dx6ajy0d8m_AEvN8CmD22IeHKx_zE1oKSD6_UG-wutnT_zFY3kf_dUG60MQ_0558W042DSlXG_fpx7A7F4jucygv3U_0FmcymyA</recordid><startdate>200107</startdate><enddate>200107</enddate><creator>Ding, Jing</creator><creator>Drewes, Charles D.</creator><creator>Hsu, Walter H.</creator><general>Wiley Periodicals, Inc</general><general>SETAC</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7QH</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>200107</creationdate><title>Behavioral effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus</title><author>Ding, Jing ; Drewes, Charles D. ; Hsu, Walter H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5364-c25f04a36f534c208ae583285d0b0057b5683faa48056479e686546693b469a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Anthelmintics - adverse effects</topic><topic>Applied ecology</topic><topic>Behavior</topic><topic>Behavior, Animal</topic><topic>Biological and medical sciences</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on protozoa and invertebrates</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Interneurons - drug effects</topic><topic>Interneurons - physiology</topic><topic>Invertebrate</topic><topic>Ivermectin</topic><topic>Ivermectin - adverse effects</topic><topic>Lethal Dose 50</topic><topic>Locomotion</topic><topic>Locomotion - drug effects</topic><topic>Lumbriculus variegatus</topic><topic>Oligochaeta</topic><topic>picrotoxin</topic><topic>Sublethal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Jing</creatorcontrib><creatorcontrib>Drewes, Charles D.</creatorcontrib><creatorcontrib>Hsu, Walter H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Aqualine</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Environmental toxicology and chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Jing</au><au>Drewes, Charles D.</au><au>Hsu, Walter H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus</atitle><jtitle>Environmental toxicology and chemistry</jtitle><addtitle>Environmental Toxicology and Chemistry</addtitle><date>2001-07</date><risdate>2001</risdate><volume>20</volume><issue>7</issue><spage>1584</spage><epage>1590</epage><pages>1584-1590</pages><issn>0730-7268</issn><eissn>1552-8618</eissn><coden>ETOCDK</coden><abstract>Ivermectin is a potent antiparasitic drug against nematode and arthropod parasites. In this study, we examined the lethal and sublethal effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus. The median lethal concentration (LC50) at 72 h after ivermectin exposure was 560 nM. Sublethal endpoints focused on several stimulus‐evoked locomotor behaviors: escape reflexes controlled by giant interneuron pathways, swimming and reversal, and crawling. Swimming, reversal, and crawling are controlled by nongiant interneuron pathways. Ivermectin inhibited swimming, reversal, crawling frequency, and crawling speed in a time‐ and concentration‐dependent manner with a mean inhibitory concentration (IC50) at 3 h of 1.1, 16, 91, and 51nM, respectively. Ivermectin at 0.3 nM also significantly decreased the frequency of helical swimming waves. Picrotoxin, a Cl− channel blocker, antagonized the ivermectin‐induced decrease in swimming frequency, crawling frequency, and crawling speed. There were no adverse effects on escape reflex 3 h after exposure to 300 nM ivermectin. Electrophysiological recordings showed that ivermectin had no effects on the conduction velocity of giant fiber systems. The results indicated that locomotor behaviors controlled by nongiant locomotor pathways were more sensitive to ivermectin than pathways controlled by giant interneurons and that Cl− channels may be involved in mediating ivermectin's inhibitory effects.</abstract><cop>Hoboken</cop><pub>Wiley Periodicals, Inc</pub><pmid>11434302</pmid><doi>10.1002/etc.5620200724</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0730-7268 |
| ispartof | Environmental toxicology and chemistry, 2001-07, Vol.20 (7), p.1584-1590 |
| issn | 0730-7268 1552-8618 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18193866 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animal, plant and microbial ecology Animals Anthelmintics - adverse effects Applied ecology Behavior Behavior, Animal Biological and medical sciences Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on protozoa and invertebrates Fundamental and applied biological sciences. Psychology Interneurons - drug effects Interneurons - physiology Invertebrate Ivermectin Ivermectin - adverse effects Lethal Dose 50 Locomotion Locomotion - drug effects Lumbriculus variegatus Oligochaeta picrotoxin Sublethal |
| title | Behavioral effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T02%3A43%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Behavioral%20effects%20of%20ivermectin%20in%20a%20freshwater%20oligochaete,%20Lumbriculus%20variegatus&rft.jtitle=Environmental%20toxicology%20and%20chemistry&rft.au=Ding,%20Jing&rft.date=2001-07&rft.volume=20&rft.issue=7&rft.spage=1584&rft.epage=1590&rft.pages=1584-1590&rft.issn=0730-7268&rft.eissn=1552-8618&rft.coden=ETOCDK&rft_id=info:doi/10.1002/etc.5620200724&rft_dat=%3Cproquest_cross%3E14581611%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14581611&rft_id=info:pmid/11434302&rfr_iscdi=true |